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An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners

The aim of this cross-sectional study is to propose an efficient strategy based on biomarkers adjunct with an interview/questionnaire covering risk factors for periodontitis for the identification of undiagnosed periodontitis by medical professionals. Active matrix metalloproteinase (aMMP)-8 levels...

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Autores principales: Räisänen, Ismo T., Lähteenmäki, Hanna, Gupta, Shipra, Grigoriadis, Andreas, Sahni, Vaibhav, Suojanen, Juho, Seppänen, Hanna, Tervahartiala, Taina, Sakellari, Dimitra, Sorsa, Timo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071538/
https://www.ncbi.nlm.nih.gov/pubmed/33921148
http://dx.doi.org/10.3390/diagnostics11040711
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author Räisänen, Ismo T.
Lähteenmäki, Hanna
Gupta, Shipra
Grigoriadis, Andreas
Sahni, Vaibhav
Suojanen, Juho
Seppänen, Hanna
Tervahartiala, Taina
Sakellari, Dimitra
Sorsa, Timo
author_facet Räisänen, Ismo T.
Lähteenmäki, Hanna
Gupta, Shipra
Grigoriadis, Andreas
Sahni, Vaibhav
Suojanen, Juho
Seppänen, Hanna
Tervahartiala, Taina
Sakellari, Dimitra
Sorsa, Timo
author_sort Räisänen, Ismo T.
collection PubMed
description The aim of this cross-sectional study is to propose an efficient strategy based on biomarkers adjunct with an interview/questionnaire covering risk factors for periodontitis for the identification of undiagnosed periodontitis by medical professionals. Active matrix metalloproteinase (aMMP)-8 levels in mouthrinse were analyzed by a point-of-care (PoC)/chairside lateral-flow immunotest, and salivary total MMP-8, total MMP-9 and calprotectin levels were analyzed by enzyme-linked immunosorbent assays (ELISAs) and active MMP-9 by gelatin zymography for 149 Greek patients. Patients underwent a full-mouth oral health examination for diagnosis according to the 2018 classification system of periodontal diseases. In addition, patient characteristics (risk factors: age, gender, education level, smoking and body mass index) were recorded. Receiver operating curve (ROC) analysis indicated better diagnostic precision to identify undiagnosed periodontitis for oral fluid biomarkers in adjunct with an interview/questionnaire compared with a plain questionnaire (i.e., risk factors): aMMP-8 AUC (95% confidence interval) = 0.834 (0.761−0.906), total MMP-8 = 0.800 (0.722–0.878), active MMP-9 = 0.787 (0.704–0.870), total MMP-9 = 0.773 (0.687−0.858) and calprotectin = 0.773 (0.687–0.858) vs. questionnaire = 0.764 (0.676–0.851). The findings of this study suggest that oral fluid biomarker analysis, such as a rapid aMMP-8 PoC immunotest, could be used as an adjunct to an interview/questionnaire to improve the precision of timely identification of asymptomatic, undiagnosed periodontitis patients by medical professionals. This strategy appears to be viable for referring patients to a dentist for diagnosis and treatment need assessment.
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spelling pubmed-80715382021-04-26 An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners Räisänen, Ismo T. Lähteenmäki, Hanna Gupta, Shipra Grigoriadis, Andreas Sahni, Vaibhav Suojanen, Juho Seppänen, Hanna Tervahartiala, Taina Sakellari, Dimitra Sorsa, Timo Diagnostics (Basel) Communication The aim of this cross-sectional study is to propose an efficient strategy based on biomarkers adjunct with an interview/questionnaire covering risk factors for periodontitis for the identification of undiagnosed periodontitis by medical professionals. Active matrix metalloproteinase (aMMP)-8 levels in mouthrinse were analyzed by a point-of-care (PoC)/chairside lateral-flow immunotest, and salivary total MMP-8, total MMP-9 and calprotectin levels were analyzed by enzyme-linked immunosorbent assays (ELISAs) and active MMP-9 by gelatin zymography for 149 Greek patients. Patients underwent a full-mouth oral health examination for diagnosis according to the 2018 classification system of periodontal diseases. In addition, patient characteristics (risk factors: age, gender, education level, smoking and body mass index) were recorded. Receiver operating curve (ROC) analysis indicated better diagnostic precision to identify undiagnosed periodontitis for oral fluid biomarkers in adjunct with an interview/questionnaire compared with a plain questionnaire (i.e., risk factors): aMMP-8 AUC (95% confidence interval) = 0.834 (0.761−0.906), total MMP-8 = 0.800 (0.722–0.878), active MMP-9 = 0.787 (0.704–0.870), total MMP-9 = 0.773 (0.687−0.858) and calprotectin = 0.773 (0.687–0.858) vs. questionnaire = 0.764 (0.676–0.851). The findings of this study suggest that oral fluid biomarker analysis, such as a rapid aMMP-8 PoC immunotest, could be used as an adjunct to an interview/questionnaire to improve the precision of timely identification of asymptomatic, undiagnosed periodontitis patients by medical professionals. This strategy appears to be viable for referring patients to a dentist for diagnosis and treatment need assessment. MDPI 2021-04-15 /pmc/articles/PMC8071538/ /pubmed/33921148 http://dx.doi.org/10.3390/diagnostics11040711 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Räisänen, Ismo T.
Lähteenmäki, Hanna
Gupta, Shipra
Grigoriadis, Andreas
Sahni, Vaibhav
Suojanen, Juho
Seppänen, Hanna
Tervahartiala, Taina
Sakellari, Dimitra
Sorsa, Timo
An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners
title An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners
title_full An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners
title_fullStr An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners
title_full_unstemmed An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners
title_short An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners
title_sort ammp-8 point-of-care and questionnaire based real-time diagnostic toolkit for medical practitioners
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071538/
https://www.ncbi.nlm.nih.gov/pubmed/33921148
http://dx.doi.org/10.3390/diagnostics11040711
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