Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria

INTRODUCTION: Primary hyperoxaluria (PH) is a family of 3 rare genetic disorders of hepatic glyoxylate metabolism that lead to overproduction and increased renal excretion of oxalate resulting in progressive renal damage. LDHA inhibition of glyoxylate-to-oxalate conversion by RNA interference (RNAi)...

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Detalles Bibliográficos
Autores principales: Ariceta, Gema, Barrios, Kelly, Brown, Bob D., Hoppe, Bernd, Rosskamp, Ralf, Langman, Craig B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071644/
https://www.ncbi.nlm.nih.gov/pubmed/33912759
http://dx.doi.org/10.1016/j.ekir.2021.01.029

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