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Lipid–protein forces predict conformational changes in a mechanosensitive channel
The mechanosensitive TREK-2 potassium channel, a member of the K2P family, has essential physiological roles and is, therefore, a pharmaceutical target. A combination of experimental and computational studies have established that of the two known conformations, “up” and “down”, membrane tension dir...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071793/ https://www.ncbi.nlm.nih.gov/pubmed/33355710 http://dx.doi.org/10.1007/s00249-020-01488-z |