Inaccessible LCG Promoters Act as Safeguards to Restrict T Cell Development to Appropriate Notch Signaling Environments

T cell development is restricted to the thymus and is dependent on high levels of Notch signaling induced within the thymic microenvironment. To understand Notch function in thymic restriction, we investigated the basis for target gene selectivity in response to quantitative differences in Notch sig...

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Detalles Bibliográficos
Autores principales: Furuyama, Suzanne, Wu, Qian “Vicky”, Varnum-Finney, Barbara, Sandstrom, Richard, Meuleman, Wouter, Stamatoyannopoulos, John A., Bernstein, Irwin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072033/
https://www.ncbi.nlm.nih.gov/pubmed/33770495
http://dx.doi.org/10.1016/j.stemcr.2021.02.017

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