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Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways

Curcumin [(1E,6E) ‑1,7‑bis(4‑hydroxy‑3‑methoxyphenyl) hepta‑1,6‑diene‑3,5‑ dione] is a natural polyphenol derived from the rhizome of the turmeric plant Curcuma longa. Accumulated evidences have presented curcumin’s function in terms of anti-inflammatory, antioxidant properties, and especially anti-...

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Autores principales: Wang, Haijun, Zhang, Ke, Liu, Jia, Yang, Jie, Tian, Yidan, Yang, Chen, Li, Yushan, Shao, Minglong, Su, Wei, Song, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072122/
https://www.ncbi.nlm.nih.gov/pubmed/33912467
http://dx.doi.org/10.3389/fonc.2021.660712
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author Wang, Haijun
Zhang, Ke
Liu, Jia
Yang, Jie
Tian, Yidan
Yang, Chen
Li, Yushan
Shao, Minglong
Su, Wei
Song, Na
author_facet Wang, Haijun
Zhang, Ke
Liu, Jia
Yang, Jie
Tian, Yidan
Yang, Chen
Li, Yushan
Shao, Minglong
Su, Wei
Song, Na
author_sort Wang, Haijun
collection PubMed
description Curcumin [(1E,6E) ‑1,7‑bis(4‑hydroxy‑3‑methoxyphenyl) hepta‑1,6‑diene‑3,5‑ dione] is a natural polyphenol derived from the rhizome of the turmeric plant Curcuma longa. Accumulated evidences have presented curcumin’s function in terms of anti-inflammatory, antioxidant properties, and especially anti-tumor activities. Studies demonstrated that curcumin could exert anti-tumor activity via multiple biological signaling pathways, such as PI3K/Akt, JAK/STAT, MAPK, Wnt/β-catenin, p53, NF-ĸB and apoptosis related signaling pathways. Moreover, Curcumin can inhibit tumor proliferation, angiogenesis, epithelial-mesenchymal transition (EMT), invasion and metastasis by regulating tumor related non-coding RNA (ncRNA) expression. In this review, we summarized the roles of curcumin in regulating signaling pathways and ncRNAs in different kinds of cancers. We also discussed the regulatory effect of curcumin through inhibiting carcinogenic miRNA and up regulating tumor suppressive miRNA. Furthermore, we aim to illustrate the cross regulatory relationship between ncRNA and signaling pathways, further to get a better understanding of the anti-tumor mechanism of curcumin, thus lay a theoretical foundation for the clinical application of curcumin in the future.
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spelling pubmed-80721222021-04-27 Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways Wang, Haijun Zhang, Ke Liu, Jia Yang, Jie Tian, Yidan Yang, Chen Li, Yushan Shao, Minglong Su, Wei Song, Na Front Oncol Oncology Curcumin [(1E,6E) ‑1,7‑bis(4‑hydroxy‑3‑methoxyphenyl) hepta‑1,6‑diene‑3,5‑ dione] is a natural polyphenol derived from the rhizome of the turmeric plant Curcuma longa. Accumulated evidences have presented curcumin’s function in terms of anti-inflammatory, antioxidant properties, and especially anti-tumor activities. Studies demonstrated that curcumin could exert anti-tumor activity via multiple biological signaling pathways, such as PI3K/Akt, JAK/STAT, MAPK, Wnt/β-catenin, p53, NF-ĸB and apoptosis related signaling pathways. Moreover, Curcumin can inhibit tumor proliferation, angiogenesis, epithelial-mesenchymal transition (EMT), invasion and metastasis by regulating tumor related non-coding RNA (ncRNA) expression. In this review, we summarized the roles of curcumin in regulating signaling pathways and ncRNAs in different kinds of cancers. We also discussed the regulatory effect of curcumin through inhibiting carcinogenic miRNA and up regulating tumor suppressive miRNA. Furthermore, we aim to illustrate the cross regulatory relationship between ncRNA and signaling pathways, further to get a better understanding of the anti-tumor mechanism of curcumin, thus lay a theoretical foundation for the clinical application of curcumin in the future. Frontiers Media S.A. 2021-04-12 /pmc/articles/PMC8072122/ /pubmed/33912467 http://dx.doi.org/10.3389/fonc.2021.660712 Text en Copyright © 2021 Wang, Zhang, Liu, Yang, Tian, Yang, Li, Shao, Su and Song https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Haijun
Zhang, Ke
Liu, Jia
Yang, Jie
Tian, Yidan
Yang, Chen
Li, Yushan
Shao, Minglong
Su, Wei
Song, Na
Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
title Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
title_full Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
title_fullStr Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
title_full_unstemmed Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
title_short Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
title_sort curcumin regulates cancer progression: focus on ncrnas and molecular signaling pathways
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072122/
https://www.ncbi.nlm.nih.gov/pubmed/33912467
http://dx.doi.org/10.3389/fonc.2021.660712
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