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Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman

Patient: Female, 62-year-old Final Diagnosis: Takotsubo syndrome Symptoms: Chest pain Medication: — Clinical Procedure: Coronarography Specialty: Cardiology • Oncology OBJECTIVE: Unknown ethiology BACKGROUND: The main causes for takotsubo syndrome (TS) in oncological patients are stress related to c...

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Autores principales: Zalewska-Adamiec, Małgorzata, Klonowska, Paulina, Małyszko, Jolanta, Kuźma, Łukasz, Bachorzewska-Gajewska, Hanna, Dobrzycki, Sławomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072183/
https://www.ncbi.nlm.nih.gov/pubmed/33875632
http://dx.doi.org/10.12659/AJCR.930090
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author Zalewska-Adamiec, Małgorzata
Klonowska, Paulina
Małyszko, Jolanta
Kuźma, Łukasz
Bachorzewska-Gajewska, Hanna
Dobrzycki, Sławomir
author_facet Zalewska-Adamiec, Małgorzata
Klonowska, Paulina
Małyszko, Jolanta
Kuźma, Łukasz
Bachorzewska-Gajewska, Hanna
Dobrzycki, Sławomir
author_sort Zalewska-Adamiec, Małgorzata
collection PubMed
description Patient: Female, 62-year-old Final Diagnosis: Takotsubo syndrome Symptoms: Chest pain Medication: — Clinical Procedure: Coronarography Specialty: Cardiology • Oncology OBJECTIVE: Unknown ethiology BACKGROUND: The main causes for takotsubo syndrome (TS) in oncological patients are stress related to cancer diagnosis and treatment, pain in the course of the disease, treatment complications, and paraneoplastic syndromes. CASE REPORT: An obese 62-year-old female patient, with a 3-day history of chest pain, was admitted to the hospital with a suspected acute coronary event. She had been diagnosed with high-grade bladder cancer 6 months before. After the transurethral electroresection of the tumor 5 months before and subsequent chemotherapy (gemcitabine and cisplatin), the patient was qualified for the next cancer surgery. On admission, the patient remained without chest pain. The ECG record demonstrated inverted T waves in the leads from above the anterior and lateral wall. The coronarography demonstrated minor atherosclerotic changes in the coronary arteries. The left ventriculography presented akinesis of the apex and the apical and mid-segment of the anterior wall, and the ejection fraction (EF) was 38%. Takotsubo syndrome was diagnosed. Laboratory testing revealed elevated concentration of troponin and N-terminal pro-B-type natriuretic peptide. The subsequent ECG records demonstrated deeply inverted T waves and numerous ventricular premature beats and increased QTc (528 ms). A control echocardiography showed improved left ventricular contractive function (EF – 47%). On the 4(th) day of hospitalization, the patient was discharged and referred for further oncological treatment. CONCLUSIONS: The diagnosis of TS in oncology patients is difficult, especially in the presence of atherosclerotic lesions in coronary arteries. Takotsubo syndrome in cancer patients delays the next stages of oncological treatment, which worsens the prognosis of these patients.
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spelling pubmed-80721832021-05-04 Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman Zalewska-Adamiec, Małgorzata Klonowska, Paulina Małyszko, Jolanta Kuźma, Łukasz Bachorzewska-Gajewska, Hanna Dobrzycki, Sławomir Am J Case Rep Articles Patient: Female, 62-year-old Final Diagnosis: Takotsubo syndrome Symptoms: Chest pain Medication: — Clinical Procedure: Coronarography Specialty: Cardiology • Oncology OBJECTIVE: Unknown ethiology BACKGROUND: The main causes for takotsubo syndrome (TS) in oncological patients are stress related to cancer diagnosis and treatment, pain in the course of the disease, treatment complications, and paraneoplastic syndromes. CASE REPORT: An obese 62-year-old female patient, with a 3-day history of chest pain, was admitted to the hospital with a suspected acute coronary event. She had been diagnosed with high-grade bladder cancer 6 months before. After the transurethral electroresection of the tumor 5 months before and subsequent chemotherapy (gemcitabine and cisplatin), the patient was qualified for the next cancer surgery. On admission, the patient remained without chest pain. The ECG record demonstrated inverted T waves in the leads from above the anterior and lateral wall. The coronarography demonstrated minor atherosclerotic changes in the coronary arteries. The left ventriculography presented akinesis of the apex and the apical and mid-segment of the anterior wall, and the ejection fraction (EF) was 38%. Takotsubo syndrome was diagnosed. Laboratory testing revealed elevated concentration of troponin and N-terminal pro-B-type natriuretic peptide. The subsequent ECG records demonstrated deeply inverted T waves and numerous ventricular premature beats and increased QTc (528 ms). A control echocardiography showed improved left ventricular contractive function (EF – 47%). On the 4(th) day of hospitalization, the patient was discharged and referred for further oncological treatment. CONCLUSIONS: The diagnosis of TS in oncology patients is difficult, especially in the presence of atherosclerotic lesions in coronary arteries. Takotsubo syndrome in cancer patients delays the next stages of oncological treatment, which worsens the prognosis of these patients. International Scientific Literature, Inc. 2021-04-20 /pmc/articles/PMC8072183/ /pubmed/33875632 http://dx.doi.org/10.12659/AJCR.930090 Text en © Am J Case Rep, 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Zalewska-Adamiec, Małgorzata
Klonowska, Paulina
Małyszko, Jolanta
Kuźma, Łukasz
Bachorzewska-Gajewska, Hanna
Dobrzycki, Sławomir
Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman
title Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman
title_full Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman
title_fullStr Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman
title_full_unstemmed Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman
title_short Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman
title_sort primary takotsubo syndrome as a complication of bladder cancer treatment in a 62-year-old woman
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072183/
https://www.ncbi.nlm.nih.gov/pubmed/33875632
http://dx.doi.org/10.12659/AJCR.930090
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