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Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing

Myosin-based regulation in the heart muscle modulates the number of myosin motors available for interaction with calcium-regulated thin filaments, but the signaling pathways mediating the stronger contraction triggered by stretch between heartbeats or by phosphorylation of the myosin regulatory ligh...

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Detalles Bibliográficos
Autores principales: Park-Holohan, So-Jin, Brunello, Elisabetta, Kampourakis, Thomas, Rees, Martin, Irving, Malcolm, Fusi, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072254/
https://www.ncbi.nlm.nih.gov/pubmed/33850019
http://dx.doi.org/10.1073/pnas.2023706118

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