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Simultaneous Optimization of Oral and Transdermal Nanovesicles for Bioavailability Enhancement of Ivabradine Hydrochloride

PURPOSE: Ivabradine hydrochloride is selective pacemaker current (I(f)) ion channel inhibitor used in case of chronic heart failure (CHF) with superior efficacy and lower side effects than most β-blockers. However, the drug suffers from low bioavailability (≈40%) due to extensive first-pass metaboli...

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Detalles Bibliográficos
Autores principales:	Naguib, Marianne Joseph, Elsayed, Ibrahim, Teaima, Mahmoud Hassan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072262/ https://www.ncbi.nlm.nih.gov/pubmed/33911861 http://dx.doi.org/10.2147/IJN.S299326

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