The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway

In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 coul...

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Detalles Bibliográficos
Autores principales: Tang, Chun, Wang, Xuehui, Ji, Changle, Zheng, Wenfang, Yu, Yunhe, Deng, Xiaochong, Zhou, Xiqian, Fang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072343/
https://www.ncbi.nlm.nih.gov/pubmed/33912460
http://dx.doi.org/10.3389/fonc.2021.645682
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author Tang, Chun
Wang, Xuehui
Ji, Changle
Zheng, Wenfang
Yu, Yunhe
Deng, Xiaochong
Zhou, Xiqian
Fang, Lin
author_facet Tang, Chun
Wang, Xuehui
Ji, Changle
Zheng, Wenfang
Yu, Yunhe
Deng, Xiaochong
Zhou, Xiqian
Fang, Lin
author_sort Tang, Chun
collection PubMed
description In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/β-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis via Wnt/β-catenin signaling pathway, which might be novel targets for BC targeted therapy.
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spelling pubmed-80723432021-04-27 The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway Tang, Chun Wang, Xuehui Ji, Changle Zheng, Wenfang Yu, Yunhe Deng, Xiaochong Zhou, Xiqian Fang, Lin Front Oncol Oncology In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/β-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis via Wnt/β-catenin signaling pathway, which might be novel targets for BC targeted therapy. Frontiers Media S.A. 2021-04-12 /pmc/articles/PMC8072343/ /pubmed/33912460 http://dx.doi.org/10.3389/fonc.2021.645682 Text en Copyright © 2021 Tang, Wang, Ji, Zheng, Yu, Deng, Zhou and Fang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tang, Chun
Wang, Xuehui
Ji, Changle
Zheng, Wenfang
Yu, Yunhe
Deng, Xiaochong
Zhou, Xiqian
Fang, Lin
The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway
title The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway
title_full The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway
title_fullStr The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway
title_full_unstemmed The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway
title_short The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway
title_sort role of mir-640: a potential suppressor in breast cancer via wnt7b/β-catenin signaling pathway
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072343/
https://www.ncbi.nlm.nih.gov/pubmed/33912460
http://dx.doi.org/10.3389/fonc.2021.645682
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