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Practicality of 3D Printed Personalized Medicines in Therapeutics

Technological advances in science over the past century have paved the way for remedial treatment outcomes in various diseases. Pharmacogenomic predispositions, the emergence of multidrug resistance, medication and formulation errors contribute significantly to patient mortality. The concept of “per...

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Autores principales: Amekyeh, Hilda, Tarlochan, Faris, Billa, Nashiru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072378/
https://www.ncbi.nlm.nih.gov/pubmed/33912058
http://dx.doi.org/10.3389/fphar.2021.646836
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author Amekyeh, Hilda
Tarlochan, Faris
Billa, Nashiru
author_facet Amekyeh, Hilda
Tarlochan, Faris
Billa, Nashiru
author_sort Amekyeh, Hilda
collection PubMed
description Technological advances in science over the past century have paved the way for remedial treatment outcomes in various diseases. Pharmacogenomic predispositions, the emergence of multidrug resistance, medication and formulation errors contribute significantly to patient mortality. The concept of “personalized” or “precision” medicines provides a window to addressing these issues and hence reducing mortality. The emergence of three-dimensional printing of medicines over the past decades has generated interests in therapeutics and dispensing, whereby the provisions of personalized medicines can be built within the framework of producing medicines at dispensaries or pharmacies. This plan is a good replacement of the fit-for-all modality in conventional therapeutics, where clinicians are constrained to prescribe pre-formulated dose units available on the market. However, three-dimension printing of personalized medicines faces several hurdles, but these are not insurmountable. In this review, we explore the relevance of personalized medicines in therapeutics and how three-dimensional printing makes a good fit in current gaps within conventional therapeutics in order to secure an effective implementation of personalized medicines. We also explore the deployment of three-dimensional printing of personalized medicines based on practical, legal and regulatory provisions.
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spelling pubmed-80723782021-04-27 Practicality of 3D Printed Personalized Medicines in Therapeutics Amekyeh, Hilda Tarlochan, Faris Billa, Nashiru Front Pharmacol Pharmacology Technological advances in science over the past century have paved the way for remedial treatment outcomes in various diseases. Pharmacogenomic predispositions, the emergence of multidrug resistance, medication and formulation errors contribute significantly to patient mortality. The concept of “personalized” or “precision” medicines provides a window to addressing these issues and hence reducing mortality. The emergence of three-dimensional printing of medicines over the past decades has generated interests in therapeutics and dispensing, whereby the provisions of personalized medicines can be built within the framework of producing medicines at dispensaries or pharmacies. This plan is a good replacement of the fit-for-all modality in conventional therapeutics, where clinicians are constrained to prescribe pre-formulated dose units available on the market. However, three-dimension printing of personalized medicines faces several hurdles, but these are not insurmountable. In this review, we explore the relevance of personalized medicines in therapeutics and how three-dimensional printing makes a good fit in current gaps within conventional therapeutics in order to secure an effective implementation of personalized medicines. We also explore the deployment of three-dimensional printing of personalized medicines based on practical, legal and regulatory provisions. Frontiers Media S.A. 2021-04-12 /pmc/articles/PMC8072378/ /pubmed/33912058 http://dx.doi.org/10.3389/fphar.2021.646836 Text en Copyright © 2021 Amekyeh, Tarlochan and Billa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Amekyeh, Hilda
Tarlochan, Faris
Billa, Nashiru
Practicality of 3D Printed Personalized Medicines in Therapeutics
title Practicality of 3D Printed Personalized Medicines in Therapeutics
title_full Practicality of 3D Printed Personalized Medicines in Therapeutics
title_fullStr Practicality of 3D Printed Personalized Medicines in Therapeutics
title_full_unstemmed Practicality of 3D Printed Personalized Medicines in Therapeutics
title_short Practicality of 3D Printed Personalized Medicines in Therapeutics
title_sort practicality of 3d printed personalized medicines in therapeutics
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072378/
https://www.ncbi.nlm.nih.gov/pubmed/33912058
http://dx.doi.org/10.3389/fphar.2021.646836
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