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Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein

Metabolic syndrome (MetS) affects the population worldwide and results from several factors such as genetic background, environment and lifestyle. In recent years, an interplay among autophagy, metabolism, and metabolic disorders has become apparent. Defects in the autophagy machinery are associated...

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Autores principales: Frisardi, Vincenza, Matrone, Carmela, Street, Maria Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072385/
https://www.ncbi.nlm.nih.gov/pubmed/33912566
http://dx.doi.org/10.3389/fcell.2021.654913
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author Frisardi, Vincenza
Matrone, Carmela
Street, Maria Elisabeth
author_facet Frisardi, Vincenza
Matrone, Carmela
Street, Maria Elisabeth
author_sort Frisardi, Vincenza
collection PubMed
description Metabolic syndrome (MetS) affects the population worldwide and results from several factors such as genetic background, environment and lifestyle. In recent years, an interplay among autophagy, metabolism, and metabolic disorders has become apparent. Defects in the autophagy machinery are associated with the dysfunction of many tissues/organs regulating metabolism. Metabolic hormones and nutrients regulate, in turn, the autophagy mechanism. Autophagy is a housekeeping stress-induced degradation process that ensures cellular homeostasis. High mobility group box 1 (HMGB1) is a highly conserved nuclear protein with a nuclear and extracellular role that functions as an extracellular signaling molecule under specific conditions. Several studies have shown that HMGB1 is a critical regulator of autophagy. This mini-review focuses on the involvement of HMGB1 protein in the interplay between autophagy and MetS, emphasizing its potential role as a promising biomarker candidate for the early stage of MetS or disease’s therapeutic target.
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spelling pubmed-80723852021-04-27 Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein Frisardi, Vincenza Matrone, Carmela Street, Maria Elisabeth Front Cell Dev Biol Cell and Developmental Biology Metabolic syndrome (MetS) affects the population worldwide and results from several factors such as genetic background, environment and lifestyle. In recent years, an interplay among autophagy, metabolism, and metabolic disorders has become apparent. Defects in the autophagy machinery are associated with the dysfunction of many tissues/organs regulating metabolism. Metabolic hormones and nutrients regulate, in turn, the autophagy mechanism. Autophagy is a housekeeping stress-induced degradation process that ensures cellular homeostasis. High mobility group box 1 (HMGB1) is a highly conserved nuclear protein with a nuclear and extracellular role that functions as an extracellular signaling molecule under specific conditions. Several studies have shown that HMGB1 is a critical regulator of autophagy. This mini-review focuses on the involvement of HMGB1 protein in the interplay between autophagy and MetS, emphasizing its potential role as a promising biomarker candidate for the early stage of MetS or disease’s therapeutic target. Frontiers Media S.A. 2021-04-12 /pmc/articles/PMC8072385/ /pubmed/33912566 http://dx.doi.org/10.3389/fcell.2021.654913 Text en Copyright © 2021 Frisardi, Matrone and Street. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Frisardi, Vincenza
Matrone, Carmela
Street, Maria Elisabeth
Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
title Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
title_full Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
title_fullStr Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
title_full_unstemmed Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
title_short Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
title_sort metabolic syndrome and autophagy: focus on hmgb1 protein
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072385/
https://www.ncbi.nlm.nih.gov/pubmed/33912566
http://dx.doi.org/10.3389/fcell.2021.654913
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