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Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
Metabolic syndrome (MetS) affects the population worldwide and results from several factors such as genetic background, environment and lifestyle. In recent years, an interplay among autophagy, metabolism, and metabolic disorders has become apparent. Defects in the autophagy machinery are associated...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072385/ https://www.ncbi.nlm.nih.gov/pubmed/33912566 http://dx.doi.org/10.3389/fcell.2021.654913 |
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author | Frisardi, Vincenza Matrone, Carmela Street, Maria Elisabeth |
author_facet | Frisardi, Vincenza Matrone, Carmela Street, Maria Elisabeth |
author_sort | Frisardi, Vincenza |
collection | PubMed |
description | Metabolic syndrome (MetS) affects the population worldwide and results from several factors such as genetic background, environment and lifestyle. In recent years, an interplay among autophagy, metabolism, and metabolic disorders has become apparent. Defects in the autophagy machinery are associated with the dysfunction of many tissues/organs regulating metabolism. Metabolic hormones and nutrients regulate, in turn, the autophagy mechanism. Autophagy is a housekeeping stress-induced degradation process that ensures cellular homeostasis. High mobility group box 1 (HMGB1) is a highly conserved nuclear protein with a nuclear and extracellular role that functions as an extracellular signaling molecule under specific conditions. Several studies have shown that HMGB1 is a critical regulator of autophagy. This mini-review focuses on the involvement of HMGB1 protein in the interplay between autophagy and MetS, emphasizing its potential role as a promising biomarker candidate for the early stage of MetS or disease’s therapeutic target. |
format | Online Article Text |
id | pubmed-8072385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80723852021-04-27 Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein Frisardi, Vincenza Matrone, Carmela Street, Maria Elisabeth Front Cell Dev Biol Cell and Developmental Biology Metabolic syndrome (MetS) affects the population worldwide and results from several factors such as genetic background, environment and lifestyle. In recent years, an interplay among autophagy, metabolism, and metabolic disorders has become apparent. Defects in the autophagy machinery are associated with the dysfunction of many tissues/organs regulating metabolism. Metabolic hormones and nutrients regulate, in turn, the autophagy mechanism. Autophagy is a housekeeping stress-induced degradation process that ensures cellular homeostasis. High mobility group box 1 (HMGB1) is a highly conserved nuclear protein with a nuclear and extracellular role that functions as an extracellular signaling molecule under specific conditions. Several studies have shown that HMGB1 is a critical regulator of autophagy. This mini-review focuses on the involvement of HMGB1 protein in the interplay between autophagy and MetS, emphasizing its potential role as a promising biomarker candidate for the early stage of MetS or disease’s therapeutic target. Frontiers Media S.A. 2021-04-12 /pmc/articles/PMC8072385/ /pubmed/33912566 http://dx.doi.org/10.3389/fcell.2021.654913 Text en Copyright © 2021 Frisardi, Matrone and Street. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Frisardi, Vincenza Matrone, Carmela Street, Maria Elisabeth Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein |
title | Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein |
title_full | Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein |
title_fullStr | Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein |
title_full_unstemmed | Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein |
title_short | Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein |
title_sort | metabolic syndrome and autophagy: focus on hmgb1 protein |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072385/ https://www.ncbi.nlm.nih.gov/pubmed/33912566 http://dx.doi.org/10.3389/fcell.2021.654913 |
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