Cargando…

Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection

The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of e...

Descripción completa

Detalles Bibliográficos
Autores principales: Pacheco-Herrero, Mar, Soto-Rojas, Luis O., Harrington, Charles R., Flores-Martinez, Yazmin M., Villegas-Rojas, Marcos M., León-Aguilar, Alfredo M., Martínez-Gómez, Paola A., Campa-Córdoba, B. Berenice, Apátiga-Pérez, Ricardo, Corniel-Taveras, Carolin N., Dominguez-García, Jesabelle de J., Blanco-Alvarez, Víctor Manuel, Luna-Muñoz, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072392/
https://www.ncbi.nlm.nih.gov/pubmed/33912129
http://dx.doi.org/10.3389/fneur.2021.660087
Descripción
Sumario:The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of evidence suggest that SARS-CoV-2 may affect the central nervous system (CNS) and cause neurological symptoms in COVID-19 patients. It is also known that angiotensin-converting enzyme-2 (ACE2), the primary receptor for SARS-CoV-2 infection, is expressed in different brain areas and cell types. Thus, it is hypothesized that infection by this virus could generate or exacerbate neuropathological alterations. However, the molecular mechanisms that link COVID-19 disease and nerve damage are unclear. In this review, we describe the routes of SARS-CoV-2 invasion into the central nervous system. We also analyze the neuropathologic mechanisms underlying this viral infection, and their potential relationship with the neurological manifestations described in patients with COVID-19, and the appearance or exacerbation of some neurodegenerative diseases.