Cargando…
Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection
The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of e...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072392/ https://www.ncbi.nlm.nih.gov/pubmed/33912129 http://dx.doi.org/10.3389/fneur.2021.660087 |
_version_ | 1783683908969168896 |
---|---|
author | Pacheco-Herrero, Mar Soto-Rojas, Luis O. Harrington, Charles R. Flores-Martinez, Yazmin M. Villegas-Rojas, Marcos M. León-Aguilar, Alfredo M. Martínez-Gómez, Paola A. Campa-Córdoba, B. Berenice Apátiga-Pérez, Ricardo Corniel-Taveras, Carolin N. Dominguez-García, Jesabelle de J. Blanco-Alvarez, Víctor Manuel Luna-Muñoz, José |
author_facet | Pacheco-Herrero, Mar Soto-Rojas, Luis O. Harrington, Charles R. Flores-Martinez, Yazmin M. Villegas-Rojas, Marcos M. León-Aguilar, Alfredo M. Martínez-Gómez, Paola A. Campa-Córdoba, B. Berenice Apátiga-Pérez, Ricardo Corniel-Taveras, Carolin N. Dominguez-García, Jesabelle de J. Blanco-Alvarez, Víctor Manuel Luna-Muñoz, José |
author_sort | Pacheco-Herrero, Mar |
collection | PubMed |
description | The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of evidence suggest that SARS-CoV-2 may affect the central nervous system (CNS) and cause neurological symptoms in COVID-19 patients. It is also known that angiotensin-converting enzyme-2 (ACE2), the primary receptor for SARS-CoV-2 infection, is expressed in different brain areas and cell types. Thus, it is hypothesized that infection by this virus could generate or exacerbate neuropathological alterations. However, the molecular mechanisms that link COVID-19 disease and nerve damage are unclear. In this review, we describe the routes of SARS-CoV-2 invasion into the central nervous system. We also analyze the neuropathologic mechanisms underlying this viral infection, and their potential relationship with the neurological manifestations described in patients with COVID-19, and the appearance or exacerbation of some neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-8072392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80723922021-04-27 Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection Pacheco-Herrero, Mar Soto-Rojas, Luis O. Harrington, Charles R. Flores-Martinez, Yazmin M. Villegas-Rojas, Marcos M. León-Aguilar, Alfredo M. Martínez-Gómez, Paola A. Campa-Córdoba, B. Berenice Apátiga-Pérez, Ricardo Corniel-Taveras, Carolin N. Dominguez-García, Jesabelle de J. Blanco-Alvarez, Víctor Manuel Luna-Muñoz, José Front Neurol Neurology The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of evidence suggest that SARS-CoV-2 may affect the central nervous system (CNS) and cause neurological symptoms in COVID-19 patients. It is also known that angiotensin-converting enzyme-2 (ACE2), the primary receptor for SARS-CoV-2 infection, is expressed in different brain areas and cell types. Thus, it is hypothesized that infection by this virus could generate or exacerbate neuropathological alterations. However, the molecular mechanisms that link COVID-19 disease and nerve damage are unclear. In this review, we describe the routes of SARS-CoV-2 invasion into the central nervous system. We also analyze the neuropathologic mechanisms underlying this viral infection, and their potential relationship with the neurological manifestations described in patients with COVID-19, and the appearance or exacerbation of some neurodegenerative diseases. Frontiers Media S.A. 2021-04-12 /pmc/articles/PMC8072392/ /pubmed/33912129 http://dx.doi.org/10.3389/fneur.2021.660087 Text en Copyright © 2021 Pacheco-Herrero, Soto-Rojas, Harrington, Flores-Martinez, Villegas-Rojas, León-Aguilar, Martínez-Gómez, Campa-Córdoba, Apátiga-Pérez, Corniel-Taveras, Dominguez-García, Blanco-Alvarez and Luna-Muñoz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Pacheco-Herrero, Mar Soto-Rojas, Luis O. Harrington, Charles R. Flores-Martinez, Yazmin M. Villegas-Rojas, Marcos M. León-Aguilar, Alfredo M. Martínez-Gómez, Paola A. Campa-Córdoba, B. Berenice Apátiga-Pérez, Ricardo Corniel-Taveras, Carolin N. Dominguez-García, Jesabelle de J. Blanco-Alvarez, Víctor Manuel Luna-Muñoz, José Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection |
title | Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection |
title_full | Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection |
title_fullStr | Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection |
title_full_unstemmed | Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection |
title_short | Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection |
title_sort | elucidating the neuropathologic mechanisms of sars-cov-2 infection |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072392/ https://www.ncbi.nlm.nih.gov/pubmed/33912129 http://dx.doi.org/10.3389/fneur.2021.660087 |
work_keys_str_mv | AT pachecoherreromar elucidatingtheneuropathologicmechanismsofsarscov2infection AT sotorojasluiso elucidatingtheneuropathologicmechanismsofsarscov2infection AT harringtoncharlesr elucidatingtheneuropathologicmechanismsofsarscov2infection AT floresmartinezyazminm elucidatingtheneuropathologicmechanismsofsarscov2infection AT villegasrojasmarcosm elucidatingtheneuropathologicmechanismsofsarscov2infection AT leonaguilaralfredom elucidatingtheneuropathologicmechanismsofsarscov2infection AT martinezgomezpaolaa elucidatingtheneuropathologicmechanismsofsarscov2infection AT campacordobabberenice elucidatingtheneuropathologicmechanismsofsarscov2infection AT apatigaperezricardo elucidatingtheneuropathologicmechanismsofsarscov2infection AT cornieltaverascarolinn elucidatingtheneuropathologicmechanismsofsarscov2infection AT dominguezgarciajesabelledej elucidatingtheneuropathologicmechanismsofsarscov2infection AT blancoalvarezvictormanuel elucidatingtheneuropathologicmechanismsofsarscov2infection AT lunamunozjose elucidatingtheneuropathologicmechanismsofsarscov2infection |