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Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment

Exosomes are secreted by different types of cells in tumor microenvironment (TME) and participate in multiple biological processes of tumors. Non-coding RNAs (ncRNAs) enveloped in exosomes and released to the TME are shown to be involved in tumorigenesis and development, as well as act as important...

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Autores principales: Chen, Qi, Li, Yuefeng, Liu, Yueqin, Xu, Wenlin, Zhu, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072401/
https://www.ncbi.nlm.nih.gov/pubmed/33912560
http://dx.doi.org/10.3389/fcell.2021.646864
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author Chen, Qi
Li, Yuefeng
Liu, Yueqin
Xu, Wenlin
Zhu, Xiaolan
author_facet Chen, Qi
Li, Yuefeng
Liu, Yueqin
Xu, Wenlin
Zhu, Xiaolan
author_sort Chen, Qi
collection PubMed
description Exosomes are secreted by different types of cells in tumor microenvironment (TME) and participate in multiple biological processes of tumors. Non-coding RNAs (ncRNAs) enveloped in exosomes and released to the TME are shown to be involved in tumorigenesis and development, as well as act as important intracellular communication mediators. However, the understanding on the exact regulatory functions and substrates of exosomal RNA is still at an early stage. In this review, we provided an overview on recent studies on exosomes mediating the modulation of both tumor cells and immune cells, then summarized the exosomal ncRNAs [such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)] secreted by tumor cells and stromal cells that exhibited potential capabilities to regulate tumor cell growth, progression, metastasis, drug resistance, and immune response. Our review may hopefully inspire a deeper understanding on the ncRNAs’ function as useful biomarkers for the diagnosis, prognosis, and as novel targets therapy for cancer.
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spelling pubmed-80724012021-04-27 Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment Chen, Qi Li, Yuefeng Liu, Yueqin Xu, Wenlin Zhu, Xiaolan Front Cell Dev Biol Cell and Developmental Biology Exosomes are secreted by different types of cells in tumor microenvironment (TME) and participate in multiple biological processes of tumors. Non-coding RNAs (ncRNAs) enveloped in exosomes and released to the TME are shown to be involved in tumorigenesis and development, as well as act as important intracellular communication mediators. However, the understanding on the exact regulatory functions and substrates of exosomal RNA is still at an early stage. In this review, we provided an overview on recent studies on exosomes mediating the modulation of both tumor cells and immune cells, then summarized the exosomal ncRNAs [such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)] secreted by tumor cells and stromal cells that exhibited potential capabilities to regulate tumor cell growth, progression, metastasis, drug resistance, and immune response. Our review may hopefully inspire a deeper understanding on the ncRNAs’ function as useful biomarkers for the diagnosis, prognosis, and as novel targets therapy for cancer. Frontiers Media S.A. 2021-04-12 /pmc/articles/PMC8072401/ /pubmed/33912560 http://dx.doi.org/10.3389/fcell.2021.646864 Text en Copyright © 2021 Chen, Li, Liu, Xu and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Qi
Li, Yuefeng
Liu, Yueqin
Xu, Wenlin
Zhu, Xiaolan
Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment
title Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment
title_full Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment
title_fullStr Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment
title_full_unstemmed Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment
title_short Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment
title_sort exosomal non-coding rnas-mediated crosstalk in the tumor microenvironment
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072401/
https://www.ncbi.nlm.nih.gov/pubmed/33912560
http://dx.doi.org/10.3389/fcell.2021.646864
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