IFITM3 incorporation sensitizes influenza A virus to antibody-mediated neutralization

The disease severity of influenza is highly variable in humans, and one genetic determinant behind these differences is the IFITM3 gene. As an effector of the interferon response, IFITM3 potently blocks cytosolic entry of influenza A virus (IAV). Here, we reveal a novel level of inhibition by IFITM3...

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Detalles Bibliográficos
Autores principales: Lanz, Caroline, Schotsaert, Michael, Magnus, Carsten, Karakus, Umut, Hunziker, Annika, Sempere Borau, Milagros, Martínez-Romero, Carles, Spieler, Eva E., Günther, Sira C., Moritz, Eva, Hale, Benjamin G., Trkola, Alexandra, García-Sastre, Adolfo, Stertz, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072448/
https://www.ncbi.nlm.nih.gov/pubmed/33882122
http://dx.doi.org/10.1084/jem.20200303

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