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Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model
Altered function or presence of inhibitory neurons is documented in autism spectrum disorders (ASD), but the mechanism underlying this alternation is poorly understood. One major subtype of inhibitory neurons altered is the parvalbumin (PV)-containing neurons with reduced density and intensity in AS...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072465/ https://www.ncbi.nlm.nih.gov/pubmed/33912009 http://dx.doi.org/10.3389/fnmol.2021.597812 |
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author | Xia, Dan Li, Li Yang, Binrang Zhou, Qiang |
author_facet | Xia, Dan Li, Li Yang, Binrang Zhou, Qiang |
author_sort | Xia, Dan |
collection | PubMed |
description | Altered function or presence of inhibitory neurons is documented in autism spectrum disorders (ASD), but the mechanism underlying this alternation is poorly understood. One major subtype of inhibitory neurons altered is the parvalbumin (PV)-containing neurons with reduced density and intensity in ASD patients and model mice. A subpopulation of PV(+) neurons expresses perineuronal nets (PNN). To better understand whether the relationship between PV and PNN is altered in ASD, we measured quantitatively the intensities of PV and PNN in single PV(+) neurons in the prelimbic prefrontal cortex (PrL-PFC) of a valproic acid (VPA) model of ASD at different ages. We found a decreased PV intensity but increased PNN intensity in VPA mice. The relationship between PV and PNN intensities is altered in VPA mice, likely due to an “abnormal” subpopulation of neurons with an altered PV-PNN relationship. Furthermore, reducing PNN level using in vivo injection of chondroitinase ABC corrects the PV expression in adult VPA mice. We suggest that the interaction between PV and PNN is disrupted in PV(+) neurons in VPA mice which may contribute to the pathology in ASD. |
format | Online Article Text |
id | pubmed-8072465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80724652021-04-27 Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model Xia, Dan Li, Li Yang, Binrang Zhou, Qiang Front Mol Neurosci Neuroscience Altered function or presence of inhibitory neurons is documented in autism spectrum disorders (ASD), but the mechanism underlying this alternation is poorly understood. One major subtype of inhibitory neurons altered is the parvalbumin (PV)-containing neurons with reduced density and intensity in ASD patients and model mice. A subpopulation of PV(+) neurons expresses perineuronal nets (PNN). To better understand whether the relationship between PV and PNN is altered in ASD, we measured quantitatively the intensities of PV and PNN in single PV(+) neurons in the prelimbic prefrontal cortex (PrL-PFC) of a valproic acid (VPA) model of ASD at different ages. We found a decreased PV intensity but increased PNN intensity in VPA mice. The relationship between PV and PNN intensities is altered in VPA mice, likely due to an “abnormal” subpopulation of neurons with an altered PV-PNN relationship. Furthermore, reducing PNN level using in vivo injection of chondroitinase ABC corrects the PV expression in adult VPA mice. We suggest that the interaction between PV and PNN is disrupted in PV(+) neurons in VPA mice which may contribute to the pathology in ASD. Frontiers Media S.A. 2021-04-12 /pmc/articles/PMC8072465/ /pubmed/33912009 http://dx.doi.org/10.3389/fnmol.2021.597812 Text en Copyright © 2021 Xia, Li, Yang and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Xia, Dan Li, Li Yang, Binrang Zhou, Qiang Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model |
title | Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model |
title_full | Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model |
title_fullStr | Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model |
title_full_unstemmed | Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model |
title_short | Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model |
title_sort | altered relationship between parvalbumin and perineuronal nets in an autism model |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072465/ https://www.ncbi.nlm.nih.gov/pubmed/33912009 http://dx.doi.org/10.3389/fnmol.2021.597812 |
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