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Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude

This study investigated the effect of a traditional hypertrophy-oriented resistance training (R(T)) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a counterbalanced fashion, 13 resistance trained males comple...

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Autores principales: Benavente, Cristina, León, Josefa, Feriche, Belén, Schoenfeld, Brad J., Bonitch-Góngora, Juan, Almeida, Filipa, Pérez-Regalado, Sergio, Padial, Paulino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072638/
https://www.ncbi.nlm.nih.gov/pubmed/33923577
http://dx.doi.org/10.3390/ijerph18084233
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author Benavente, Cristina
León, Josefa
Feriche, Belén
Schoenfeld, Brad J.
Bonitch-Góngora, Juan
Almeida, Filipa
Pérez-Regalado, Sergio
Padial, Paulino
author_facet Benavente, Cristina
León, Josefa
Feriche, Belén
Schoenfeld, Brad J.
Bonitch-Góngora, Juan
Almeida, Filipa
Pérez-Regalado, Sergio
Padial, Paulino
author_sort Benavente, Cristina
collection PubMed
description This study investigated the effect of a traditional hypertrophy-oriented resistance training (R(T)) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a counterbalanced fashion, 13 resistance trained males completed a hypertrophic R(T) session at both moderate-altitude (H; 2320 m asl) and under normoxic conditions (N; <700 m asl). Venous blood samples were taken before and throughout the 30 min post-exercise period for determination of cytokines (IL6, IL10, TNFα), hormones (growth hormone [GH], cortisol [C], testosterone), and miR-378. Both exercise conditions stimulated GH and C release, while miR-378, testosterone, and inflammatory responses remained near basal conditions. At H, the R(T) session produced a moderate to large but nonsignificant increase in the absolute peak values of the studied cytokines. miR-378 revealed a moderate association with GH (r = 0.65; p = 0.026 and r = −0.59; p = 0.051 in N and H, respectively) and C (r = 0.61; p = 0.035 and r = 0.75; p = 0.005 in N and H, respectively). The results suggest that a R(T) session at H does not differentially affect the hormonal, inflammatory, and miR-378 responses compared to N. However, the standardized mean difference detected values in the cytokines suggest an intensification of the inflammatory response in H that should be further investigated.
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spelling pubmed-80726382021-04-27 Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude Benavente, Cristina León, Josefa Feriche, Belén Schoenfeld, Brad J. Bonitch-Góngora, Juan Almeida, Filipa Pérez-Regalado, Sergio Padial, Paulino Int J Environ Res Public Health Article This study investigated the effect of a traditional hypertrophy-oriented resistance training (R(T)) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a counterbalanced fashion, 13 resistance trained males completed a hypertrophic R(T) session at both moderate-altitude (H; 2320 m asl) and under normoxic conditions (N; <700 m asl). Venous blood samples were taken before and throughout the 30 min post-exercise period for determination of cytokines (IL6, IL10, TNFα), hormones (growth hormone [GH], cortisol [C], testosterone), and miR-378. Both exercise conditions stimulated GH and C release, while miR-378, testosterone, and inflammatory responses remained near basal conditions. At H, the R(T) session produced a moderate to large but nonsignificant increase in the absolute peak values of the studied cytokines. miR-378 revealed a moderate association with GH (r = 0.65; p = 0.026 and r = −0.59; p = 0.051 in N and H, respectively) and C (r = 0.61; p = 0.035 and r = 0.75; p = 0.005 in N and H, respectively). The results suggest that a R(T) session at H does not differentially affect the hormonal, inflammatory, and miR-378 responses compared to N. However, the standardized mean difference detected values in the cytokines suggest an intensification of the inflammatory response in H that should be further investigated. MDPI 2021-04-16 /pmc/articles/PMC8072638/ /pubmed/33923577 http://dx.doi.org/10.3390/ijerph18084233 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Benavente, Cristina
León, Josefa
Feriche, Belén
Schoenfeld, Brad J.
Bonitch-Góngora, Juan
Almeida, Filipa
Pérez-Regalado, Sergio
Padial, Paulino
Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
title Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
title_full Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
title_fullStr Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
title_full_unstemmed Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
title_short Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
title_sort hormonal and inflammatory responses to hypertrophy-oriented resistance training at acute moderate altitude
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072638/
https://www.ncbi.nlm.nih.gov/pubmed/33923577
http://dx.doi.org/10.3390/ijerph18084233
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