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Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth
Background: Abdominal aortic aneurysm represents a distinct group of vascular lesions, in terms of surveillance and treatment. Screening and follow-up of patients via duplex ultrasound has been well established and proposed by current guidelines. However, serum circulating biomarkers could earn a po...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072679/ https://www.ncbi.nlm.nih.gov/pubmed/33923412 http://dx.doi.org/10.3390/jcm10081718 |
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author | Nana, Petroula Dakis, Konstantinos Brodis, Alexandros Spanos, Konstantinos Kouvelos, George |
author_facet | Nana, Petroula Dakis, Konstantinos Brodis, Alexandros Spanos, Konstantinos Kouvelos, George |
author_sort | Nana, Petroula |
collection | PubMed |
description | Background: Abdominal aortic aneurysm represents a distinct group of vascular lesions, in terms of surveillance and treatment. Screening and follow-up of patients via duplex ultrasound has been well established and proposed by current guidelines. However, serum circulating biomarkers could earn a position in individualized patient surveillance, especially in cases of aggressive AAA growth rates. A systematic review was conducted to assess the correlation of AAA expansion rates with serum circulating biomarkers. Methods: A data search of English medical literature was conducted, using PubMed, EMBASE, and CENTRAL, until 7 March 2021, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement (PRISMA) guidelines. Studies reporting on humans, on abdominal aortic aneurysm growth rates and on serum circulating biomarkers were included. No statistical analysis was conducted. Results: A total of 25 studies with 4753 patients were included. Studies were divided in two broad categories: Those reporting on clinically applicable (8 studies) and those reporting on experimental (17 studies) biomarkers. Twenty-three out of 25 studies used duplex ultrasound (DUS) for following patients. Amongst clinically applicable biomarkers, D-dimers, LDL-C, HDL-C, TC, ApoB, and HbA1c were found to bear the most significant association with AAA growth rates. In terms of the experimental biomarkers, PIIINP, osteopontin, tPA, osteopontin, haptoglobin polymorphisms, insulin-like growth factor I, thioredoxin, neutrophil extracellular traps (NETs), and genetic factors, as polymorphisms and microRNAs were positively correlated with increased AAA expansion rates. Conclusion: In the presence of future robust data, specific serum biomarkers could potentially form the basis of an individualized surveillance strategy of patients presenting with increased AAA growth rates. |
format | Online Article Text |
id | pubmed-8072679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80726792021-04-27 Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth Nana, Petroula Dakis, Konstantinos Brodis, Alexandros Spanos, Konstantinos Kouvelos, George J Clin Med Review Background: Abdominal aortic aneurysm represents a distinct group of vascular lesions, in terms of surveillance and treatment. Screening and follow-up of patients via duplex ultrasound has been well established and proposed by current guidelines. However, serum circulating biomarkers could earn a position in individualized patient surveillance, especially in cases of aggressive AAA growth rates. A systematic review was conducted to assess the correlation of AAA expansion rates with serum circulating biomarkers. Methods: A data search of English medical literature was conducted, using PubMed, EMBASE, and CENTRAL, until 7 March 2021, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement (PRISMA) guidelines. Studies reporting on humans, on abdominal aortic aneurysm growth rates and on serum circulating biomarkers were included. No statistical analysis was conducted. Results: A total of 25 studies with 4753 patients were included. Studies were divided in two broad categories: Those reporting on clinically applicable (8 studies) and those reporting on experimental (17 studies) biomarkers. Twenty-three out of 25 studies used duplex ultrasound (DUS) for following patients. Amongst clinically applicable biomarkers, D-dimers, LDL-C, HDL-C, TC, ApoB, and HbA1c were found to bear the most significant association with AAA growth rates. In terms of the experimental biomarkers, PIIINP, osteopontin, tPA, osteopontin, haptoglobin polymorphisms, insulin-like growth factor I, thioredoxin, neutrophil extracellular traps (NETs), and genetic factors, as polymorphisms and microRNAs were positively correlated with increased AAA expansion rates. Conclusion: In the presence of future robust data, specific serum biomarkers could potentially form the basis of an individualized surveillance strategy of patients presenting with increased AAA growth rates. MDPI 2021-04-16 /pmc/articles/PMC8072679/ /pubmed/33923412 http://dx.doi.org/10.3390/jcm10081718 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nana, Petroula Dakis, Konstantinos Brodis, Alexandros Spanos, Konstantinos Kouvelos, George Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth |
title | Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth |
title_full | Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth |
title_fullStr | Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth |
title_full_unstemmed | Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth |
title_short | Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth |
title_sort | circulating biomarkers for the prediction of abdominal aortic aneurysm growth |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072679/ https://www.ncbi.nlm.nih.gov/pubmed/33923412 http://dx.doi.org/10.3390/jcm10081718 |
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