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The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series
Background: In 2014, a recommended one-dose of inactivated hepatitis A vaccine was included in the Brazilian National Immunization Program targeting children 12–24 months. This decision addressed the low to intermediate endemicity status of hepatitis A across Brazil and the high rate of infection in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072696/ https://www.ncbi.nlm.nih.gov/pubmed/33924029 http://dx.doi.org/10.3390/vaccines9040407 |
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author | Bierrenbach, Ana Luiza Choi, Yoonyoung Batista, Paula de Mendonça Serra, Fernando Brandão Parellada, Cintia Irene Julian, Guilherme Silva Nakajima, Karina Moreira, Thais das Neves Fraga |
author_facet | Bierrenbach, Ana Luiza Choi, Yoonyoung Batista, Paula de Mendonça Serra, Fernando Brandão Parellada, Cintia Irene Julian, Guilherme Silva Nakajima, Karina Moreira, Thais das Neves Fraga |
author_sort | Bierrenbach, Ana Luiza |
collection | PubMed |
description | Background: In 2014, a recommended one-dose of inactivated hepatitis A vaccine was included in the Brazilian National Immunization Program targeting children 12–24 months. This decision addressed the low to intermediate endemicity status of hepatitis A across Brazil and the high rate of infection in children and adolescents between 5 and 19 years old. The aim of the study was to conduct a time-series analysis on hepatitis A incidence across age groups and to assess the hepatitis A distribution throughout Brazilian geographic regions. Methods: An interrupted time-series analysis was performed to assess hepatitis A incidence rates before (2010–2013) and after (2015–2018) hepatitis A vaccine program implementation. The time-series analysis was stratified by age groups while a secondary analysis examined geographic distribution of hepatitis A cases. Results: Overall incidence of hepatitis A decreased from 3.19/100.000 in the pre-vaccine period to 0.87/100.000 (p = 0.022) post-vaccine introduction. Incidence rate reduction was higher among children aged 1-4 years old, with an annual reduction of 67.6% in the post-vaccination period against a 7.7% annual reduction in the pre-vaccination period (p < 0.001). Between 2015 and 2018, the vaccination program prevented 14,468 hepatitis A cases. Conclusion: Our study highlighted the positive impact of a recommended one-dose inactivated hepatitis A vaccine for 1–4-years-old in controlling hepatitis A at national level. |
format | Online Article Text |
id | pubmed-8072696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80726962021-04-27 The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series Bierrenbach, Ana Luiza Choi, Yoonyoung Batista, Paula de Mendonça Serra, Fernando Brandão Parellada, Cintia Irene Julian, Guilherme Silva Nakajima, Karina Moreira, Thais das Neves Fraga Vaccines (Basel) Article Background: In 2014, a recommended one-dose of inactivated hepatitis A vaccine was included in the Brazilian National Immunization Program targeting children 12–24 months. This decision addressed the low to intermediate endemicity status of hepatitis A across Brazil and the high rate of infection in children and adolescents between 5 and 19 years old. The aim of the study was to conduct a time-series analysis on hepatitis A incidence across age groups and to assess the hepatitis A distribution throughout Brazilian geographic regions. Methods: An interrupted time-series analysis was performed to assess hepatitis A incidence rates before (2010–2013) and after (2015–2018) hepatitis A vaccine program implementation. The time-series analysis was stratified by age groups while a secondary analysis examined geographic distribution of hepatitis A cases. Results: Overall incidence of hepatitis A decreased from 3.19/100.000 in the pre-vaccine period to 0.87/100.000 (p = 0.022) post-vaccine introduction. Incidence rate reduction was higher among children aged 1-4 years old, with an annual reduction of 67.6% in the post-vaccination period against a 7.7% annual reduction in the pre-vaccination period (p < 0.001). Between 2015 and 2018, the vaccination program prevented 14,468 hepatitis A cases. Conclusion: Our study highlighted the positive impact of a recommended one-dose inactivated hepatitis A vaccine for 1–4-years-old in controlling hepatitis A at national level. MDPI 2021-04-20 /pmc/articles/PMC8072696/ /pubmed/33924029 http://dx.doi.org/10.3390/vaccines9040407 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bierrenbach, Ana Luiza Choi, Yoonyoung Batista, Paula de Mendonça Serra, Fernando Brandão Parellada, Cintia Irene Julian, Guilherme Silva Nakajima, Karina Moreira, Thais das Neves Fraga The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series |
title | The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series |
title_full | The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series |
title_fullStr | The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series |
title_full_unstemmed | The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series |
title_short | The Impact of an Inactivated Hepatitis A Vaccine with One Dose in Brazil: A Retrospective Time-Series |
title_sort | impact of an inactivated hepatitis a vaccine with one dose in brazil: a retrospective time-series |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072696/ https://www.ncbi.nlm.nih.gov/pubmed/33924029 http://dx.doi.org/10.3390/vaccines9040407 |
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