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Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System

Benefits and harms of different components of human diet have been known for hundreds of years. Alcohol is one the highest consumed, abused, and addictive substances worldwide. Consequences of alcohol abuse are increased risks for diseases of the cardiovascular system, liver, and nervous system, as...

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Autores principales: Azizov, Vugar, Zaiss, Mario M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072698/
https://www.ncbi.nlm.nih.gov/pubmed/33923766
http://dx.doi.org/10.3390/nu13041324
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author Azizov, Vugar
Zaiss, Mario M.
author_facet Azizov, Vugar
Zaiss, Mario M.
author_sort Azizov, Vugar
collection PubMed
description Benefits and harms of different components of human diet have been known for hundreds of years. Alcohol is one the highest consumed, abused, and addictive substances worldwide. Consequences of alcohol abuse are increased risks for diseases of the cardiovascular system, liver, and nervous system, as well as reduced immune system function. Paradoxically, alcohol has also been a consistent protective factor against the development of autoimmune diseases such as type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis (RA). Here, we focused on summarizing current findings on the effects of alcohol, as well as of its metabolites, acetaldehyde and acetate, on the immune system and RA. Heavy or moderate alcohol consumption can affect intestinal barrier integrity, as well as the microbiome, possibly contributing to RA. Additionally, systemic increase in acetate negatively affects humoral immune response, diminishing T(FH) cell as well as professional antigen-presenting cell (APC) function. Hence, alcohol consumption has profound effects on the efficacy of vaccinations, but also elicits protection against autoimmune diseases. The mechanism of alcohol’s negative effects on the immune system is multivariate. Future studies addressing alcohol and its metabolite acetate’s effect on individual components of the immune system remains crucial for our understanding and development of novel therapeutic pathways.
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spelling pubmed-80726982021-04-27 Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System Azizov, Vugar Zaiss, Mario M. Nutrients Review Benefits and harms of different components of human diet have been known for hundreds of years. Alcohol is one the highest consumed, abused, and addictive substances worldwide. Consequences of alcohol abuse are increased risks for diseases of the cardiovascular system, liver, and nervous system, as well as reduced immune system function. Paradoxically, alcohol has also been a consistent protective factor against the development of autoimmune diseases such as type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis (RA). Here, we focused on summarizing current findings on the effects of alcohol, as well as of its metabolites, acetaldehyde and acetate, on the immune system and RA. Heavy or moderate alcohol consumption can affect intestinal barrier integrity, as well as the microbiome, possibly contributing to RA. Additionally, systemic increase in acetate negatively affects humoral immune response, diminishing T(FH) cell as well as professional antigen-presenting cell (APC) function. Hence, alcohol consumption has profound effects on the efficacy of vaccinations, but also elicits protection against autoimmune diseases. The mechanism of alcohol’s negative effects on the immune system is multivariate. Future studies addressing alcohol and its metabolite acetate’s effect on individual components of the immune system remains crucial for our understanding and development of novel therapeutic pathways. MDPI 2021-04-16 /pmc/articles/PMC8072698/ /pubmed/33923766 http://dx.doi.org/10.3390/nu13041324 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Azizov, Vugar
Zaiss, Mario M.
Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System
title Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System
title_full Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System
title_fullStr Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System
title_full_unstemmed Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System
title_short Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System
title_sort alcohol consumption in rheumatoid arthritis: a path through the immune system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072698/
https://www.ncbi.nlm.nih.gov/pubmed/33923766
http://dx.doi.org/10.3390/nu13041324
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