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Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders?
Affective disorders (AD) including major depressive disorder (MDD) and bipolar disorder (BD) are common mood disorders associated with increased disability and poor health outcomes. Altered immune responses characterized by increased serum levels of pro-inflammatory cytokines and neuroinflammation a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072712/ https://www.ncbi.nlm.nih.gov/pubmed/33921690 http://dx.doi.org/10.3390/cells10040941 |
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author | Leite Dantas, Rafael Freff, Jana Ambrée, Oliver Beins, Eva C. Forstner, Andreas J. Dannlowski, Udo Baune, Bernhard T. Scheu, Stefanie Alferink, Judith |
author_facet | Leite Dantas, Rafael Freff, Jana Ambrée, Oliver Beins, Eva C. Forstner, Andreas J. Dannlowski, Udo Baune, Bernhard T. Scheu, Stefanie Alferink, Judith |
author_sort | Leite Dantas, Rafael |
collection | PubMed |
description | Affective disorders (AD) including major depressive disorder (MDD) and bipolar disorder (BD) are common mood disorders associated with increased disability and poor health outcomes. Altered immune responses characterized by increased serum levels of pro-inflammatory cytokines and neuroinflammation are common findings in patients with AD and in corresponding animal models. Dendritic cells (DCs) represent a heterogeneous population of myeloid cells that orchestrate innate and adaptive immune responses and self-tolerance. Upon sensing exogenous and endogenous danger signals, mature DCs secrete proinflammatory factors, acquire migratory and antigen presenting capacities and thus contribute to neuroinflammation in trauma, autoimmunity, and neurodegenerative diseases. However, little is known about the involvement of DCs in the pathogenesis of AD. In this review, we summarize the current knowledge on DCs in peripheral immune responses and neuroinflammation in MDD and BD. In addition, we consider the impact of DCs on neuroinflammation and behavior in animal models of AD. Finally, we will discuss therapeutic perspectives targeting DCs and their effector molecules in mood disorders. |
format | Online Article Text |
id | pubmed-8072712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80727122021-04-27 Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? Leite Dantas, Rafael Freff, Jana Ambrée, Oliver Beins, Eva C. Forstner, Andreas J. Dannlowski, Udo Baune, Bernhard T. Scheu, Stefanie Alferink, Judith Cells Review Affective disorders (AD) including major depressive disorder (MDD) and bipolar disorder (BD) are common mood disorders associated with increased disability and poor health outcomes. Altered immune responses characterized by increased serum levels of pro-inflammatory cytokines and neuroinflammation are common findings in patients with AD and in corresponding animal models. Dendritic cells (DCs) represent a heterogeneous population of myeloid cells that orchestrate innate and adaptive immune responses and self-tolerance. Upon sensing exogenous and endogenous danger signals, mature DCs secrete proinflammatory factors, acquire migratory and antigen presenting capacities and thus contribute to neuroinflammation in trauma, autoimmunity, and neurodegenerative diseases. However, little is known about the involvement of DCs in the pathogenesis of AD. In this review, we summarize the current knowledge on DCs in peripheral immune responses and neuroinflammation in MDD and BD. In addition, we consider the impact of DCs on neuroinflammation and behavior in animal models of AD. Finally, we will discuss therapeutic perspectives targeting DCs and their effector molecules in mood disorders. MDPI 2021-04-19 /pmc/articles/PMC8072712/ /pubmed/33921690 http://dx.doi.org/10.3390/cells10040941 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Leite Dantas, Rafael Freff, Jana Ambrée, Oliver Beins, Eva C. Forstner, Andreas J. Dannlowski, Udo Baune, Bernhard T. Scheu, Stefanie Alferink, Judith Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? |
title | Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? |
title_full | Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? |
title_fullStr | Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? |
title_full_unstemmed | Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? |
title_short | Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? |
title_sort | dendritic cells: neglected modulators of peripheral immune responses and neuroinflammation in mood disorders? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072712/ https://www.ncbi.nlm.nih.gov/pubmed/33921690 http://dx.doi.org/10.3390/cells10040941 |
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