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Engineering of Saposin C Protein Chimeras for Enhanced Cytotoxicity and Optimized Liposome Binding Capability

Saposin C (sapC) is a lysosomal, peripheral-membrane protein displaying liposome fusogenic capabilities. Proteoliposomes of sapC and phosphatidylserine have been shown to be toxic for cancer cells and are currently on clinical trial to treat glioblastoma. As proof-of-concept, we show two strategies...

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Detalles Bibliográficos
Autores principales:	Sandin, Suzanne I., Gravano, David M., Randolph, Christopher J., Sharma, Meenakshi, de Alba, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072984/ https://www.ncbi.nlm.nih.gov/pubmed/33921905 http://dx.doi.org/10.3390/pharmaceutics13040583

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