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Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa

Branching pattern formation is common in many microbes. Extensive studies have focused on addressing how such patterns emerge from local cell–cell and cell–environment interactions. However, little is known about whether and to what extent these patterns play a physiological role. Here, we consider...

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Autores principales: Luo, Nan, Wang, Shangying, Lu, Jia, Ouyang, Xiaoyi, You, Lingchong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073002/
https://www.ncbi.nlm.nih.gov/pubmed/33900031
http://dx.doi.org/10.15252/msb.202010089
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author Luo, Nan
Wang, Shangying
Lu, Jia
Ouyang, Xiaoyi
You, Lingchong
author_facet Luo, Nan
Wang, Shangying
Lu, Jia
Ouyang, Xiaoyi
You, Lingchong
author_sort Luo, Nan
collection PubMed
description Branching pattern formation is common in many microbes. Extensive studies have focused on addressing how such patterns emerge from local cell–cell and cell–environment interactions. However, little is known about whether and to what extent these patterns play a physiological role. Here, we consider the colonization of bacteria as an optimization problem to find the colony patterns that maximize colony growth efficiency under different environmental conditions. We demonstrate that Pseudomonas aeruginosa colonies develop branching patterns with characteristics comparable to the prediction of modeling; for example, colonies form thin branches in a nutrient‐poor environment. Hence, the formation of branching patterns represents an optimal strategy for the growth of Pseudomonas aeruginosa colonies. The quantitative relationship between colony patterns and growth conditions enables us to develop a coarse‐grained model to predict diverse colony patterns under more complex conditions, which we validated experimentally. Our results offer new insights into branching pattern formation as a problem‐solving social behavior in microbes and enable fast and accurate predictions of complex spatial patterns in branching colonies.
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spelling pubmed-80730022021-04-27 Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa Luo, Nan Wang, Shangying Lu, Jia Ouyang, Xiaoyi You, Lingchong Mol Syst Biol Articles Branching pattern formation is common in many microbes. Extensive studies have focused on addressing how such patterns emerge from local cell–cell and cell–environment interactions. However, little is known about whether and to what extent these patterns play a physiological role. Here, we consider the colonization of bacteria as an optimization problem to find the colony patterns that maximize colony growth efficiency under different environmental conditions. We demonstrate that Pseudomonas aeruginosa colonies develop branching patterns with characteristics comparable to the prediction of modeling; for example, colonies form thin branches in a nutrient‐poor environment. Hence, the formation of branching patterns represents an optimal strategy for the growth of Pseudomonas aeruginosa colonies. The quantitative relationship between colony patterns and growth conditions enables us to develop a coarse‐grained model to predict diverse colony patterns under more complex conditions, which we validated experimentally. Our results offer new insights into branching pattern formation as a problem‐solving social behavior in microbes and enable fast and accurate predictions of complex spatial patterns in branching colonies. John Wiley and Sons Inc. 2021-04-26 /pmc/articles/PMC8073002/ /pubmed/33900031 http://dx.doi.org/10.15252/msb.202010089 Text en © 2021 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Luo, Nan
Wang, Shangying
Lu, Jia
Ouyang, Xiaoyi
You, Lingchong
Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
title Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
title_full Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
title_fullStr Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
title_full_unstemmed Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
title_short Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
title_sort collective colony growth is optimized by branching pattern formation in pseudomonas aeruginosa
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073002/
https://www.ncbi.nlm.nih.gov/pubmed/33900031
http://dx.doi.org/10.15252/msb.202010089
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