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Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
Branching pattern formation is common in many microbes. Extensive studies have focused on addressing how such patterns emerge from local cell–cell and cell–environment interactions. However, little is known about whether and to what extent these patterns play a physiological role. Here, we consider...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073002/ https://www.ncbi.nlm.nih.gov/pubmed/33900031 http://dx.doi.org/10.15252/msb.202010089 |
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author | Luo, Nan Wang, Shangying Lu, Jia Ouyang, Xiaoyi You, Lingchong |
author_facet | Luo, Nan Wang, Shangying Lu, Jia Ouyang, Xiaoyi You, Lingchong |
author_sort | Luo, Nan |
collection | PubMed |
description | Branching pattern formation is common in many microbes. Extensive studies have focused on addressing how such patterns emerge from local cell–cell and cell–environment interactions. However, little is known about whether and to what extent these patterns play a physiological role. Here, we consider the colonization of bacteria as an optimization problem to find the colony patterns that maximize colony growth efficiency under different environmental conditions. We demonstrate that Pseudomonas aeruginosa colonies develop branching patterns with characteristics comparable to the prediction of modeling; for example, colonies form thin branches in a nutrient‐poor environment. Hence, the formation of branching patterns represents an optimal strategy for the growth of Pseudomonas aeruginosa colonies. The quantitative relationship between colony patterns and growth conditions enables us to develop a coarse‐grained model to predict diverse colony patterns under more complex conditions, which we validated experimentally. Our results offer new insights into branching pattern formation as a problem‐solving social behavior in microbes and enable fast and accurate predictions of complex spatial patterns in branching colonies. |
format | Online Article Text |
id | pubmed-8073002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80730022021-04-27 Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa Luo, Nan Wang, Shangying Lu, Jia Ouyang, Xiaoyi You, Lingchong Mol Syst Biol Articles Branching pattern formation is common in many microbes. Extensive studies have focused on addressing how such patterns emerge from local cell–cell and cell–environment interactions. However, little is known about whether and to what extent these patterns play a physiological role. Here, we consider the colonization of bacteria as an optimization problem to find the colony patterns that maximize colony growth efficiency under different environmental conditions. We demonstrate that Pseudomonas aeruginosa colonies develop branching patterns with characteristics comparable to the prediction of modeling; for example, colonies form thin branches in a nutrient‐poor environment. Hence, the formation of branching patterns represents an optimal strategy for the growth of Pseudomonas aeruginosa colonies. The quantitative relationship between colony patterns and growth conditions enables us to develop a coarse‐grained model to predict diverse colony patterns under more complex conditions, which we validated experimentally. Our results offer new insights into branching pattern formation as a problem‐solving social behavior in microbes and enable fast and accurate predictions of complex spatial patterns in branching colonies. John Wiley and Sons Inc. 2021-04-26 /pmc/articles/PMC8073002/ /pubmed/33900031 http://dx.doi.org/10.15252/msb.202010089 Text en © 2021 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Luo, Nan Wang, Shangying Lu, Jia Ouyang, Xiaoyi You, Lingchong Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa |
title | Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
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title_full | Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
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title_fullStr | Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
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title_full_unstemmed | Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
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title_short | Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa
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title_sort | collective colony growth is optimized by branching pattern formation in pseudomonas aeruginosa |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073002/ https://www.ncbi.nlm.nih.gov/pubmed/33900031 http://dx.doi.org/10.15252/msb.202010089 |
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