Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus

Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray...

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Detalles Bibliográficos
Autores principales: Xing, Cui-Ping, Chen, Dan, Xie, Chun-Lan, Liu, Qingmei, Zhong, Tian-Hua, Shao, Zongze, Liu, Guangming, Luo, Lian-Zhong, Yang, Xian-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073018/
https://www.ncbi.nlm.nih.gov/pubmed/33923496
http://dx.doi.org/10.3390/md19040224
Descripción
Sumario:Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray crystallography, Marfey’s method, and the ICD method. All isolates were tested for in vitro anti-food allergic bioactivities in immunoglobulin (Ig) E-mediated rat basophilic leukemia (RBL)-2H3 cells. Compound 13 significantly decreased the degranulation release with an IC(50) value of 60.3 μM, compared to that of 91.6 μM of the positive control, loratadine.

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