Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus

Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray...

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Autores principales: Xing, Cui-Ping, Chen, Dan, Xie, Chun-Lan, Liu, Qingmei, Zhong, Tian-Hua, Shao, Zongze, Liu, Guangming, Luo, Lian-Zhong, Yang, Xian-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073018/
https://www.ncbi.nlm.nih.gov/pubmed/33923496
http://dx.doi.org/10.3390/md19040224
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author Xing, Cui-Ping
Chen, Dan
Xie, Chun-Lan
Liu, Qingmei
Zhong, Tian-Hua
Shao, Zongze
Liu, Guangming
Luo, Lian-Zhong
Yang, Xian-Wen
author_facet Xing, Cui-Ping
Chen, Dan
Xie, Chun-Lan
Liu, Qingmei
Zhong, Tian-Hua
Shao, Zongze
Liu, Guangming
Luo, Lian-Zhong
Yang, Xian-Wen
author_sort Xing, Cui-Ping
collection PubMed
description Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray crystallography, Marfey’s method, and the ICD method. All isolates were tested for in vitro anti-food allergic bioactivities in immunoglobulin (Ig) E-mediated rat basophilic leukemia (RBL)-2H3 cells. Compound 13 significantly decreased the degranulation release with an IC(50) value of 60.3 μM, compared to that of 91.6 μM of the positive control, loratadine.
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spelling pubmed-80730182021-04-27 Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus Xing, Cui-Ping Chen, Dan Xie, Chun-Lan Liu, Qingmei Zhong, Tian-Hua Shao, Zongze Liu, Guangming Luo, Lian-Zhong Yang, Xian-Wen Mar Drugs Article Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray crystallography, Marfey’s method, and the ICD method. All isolates were tested for in vitro anti-food allergic bioactivities in immunoglobulin (Ig) E-mediated rat basophilic leukemia (RBL)-2H3 cells. Compound 13 significantly decreased the degranulation release with an IC(50) value of 60.3 μM, compared to that of 91.6 μM of the positive control, loratadine. MDPI 2021-04-16 /pmc/articles/PMC8073018/ /pubmed/33923496 http://dx.doi.org/10.3390/md19040224 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xing, Cui-Ping
Chen, Dan
Xie, Chun-Lan
Liu, Qingmei
Zhong, Tian-Hua
Shao, Zongze
Liu, Guangming
Luo, Lian-Zhong
Yang, Xian-Wen
Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus
title Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus
title_full Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus
title_fullStr Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus
title_full_unstemmed Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus
title_short Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus
title_sort anti-food allergic compounds from penicillium griseofulvum mccc 3a00225, a deep-sea-derived fungus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073018/
https://www.ncbi.nlm.nih.gov/pubmed/33923496
http://dx.doi.org/10.3390/md19040224
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