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Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin
Microencapsulation procedures have recently focused attention on designing novel microspheres via green synthesis strategies. The use of chitosan (CS) as an encapsulating material has increased interest due to its unique bioactive properties and the various crosslinking possibilities offered by thei...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073050/ https://www.ncbi.nlm.nih.gov/pubmed/33923713 http://dx.doi.org/10.3390/molecules26082325 |
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author | Correa, Rodolpho Fagundes Colucci, Giovana Halla, Noureddine Pinto, João Alves Santamaria-Echart, Arantzazu Blanco, Silvia Priscila Fernandes, Isabel Patrícia Barreiro, Maria Filomena |
author_facet | Correa, Rodolpho Fagundes Colucci, Giovana Halla, Noureddine Pinto, João Alves Santamaria-Echart, Arantzazu Blanco, Silvia Priscila Fernandes, Isabel Patrícia Barreiro, Maria Filomena |
author_sort | Correa, Rodolpho Fagundes |
collection | PubMed |
description | Microencapsulation procedures have recently focused attention on designing novel microspheres via green synthesis strategies. The use of chitosan (CS) as an encapsulating material has increased interest due to its unique bioactive properties and the various crosslinking possibilities offered by their functional groups. The consolidation of the microspheres by physical crosslinking using sodium tripolyphosphate (TPP) combined with chemical crosslinking using vanillin (VA) open new opportunities in the framework of green dual crosslinking strategies. The developed strategy, a straightforward technique based on an aqueous medium avoiding complex separation/washing steps, offers advantages over the processes based on VA, mostly using water-in-oil emulsion approaches. Thus, in this work, the combination of TPP crosslinking (3, 5, and 10 wt.%) via spray-coagulation technique with two VA crosslinking methods (in situ and post-treatment using 1 wt.% VA) were employed in the preparation of microspheres. The microspheres were characterized concerning morphology, particle size, physicochemical properties, thermal stability, and swelling behavior. Results revealed that the combination of 5 wt.% TPP with in situ VA crosslinking led to microspheres with promising properties, being an attractive alternative for natural bioactives encapsulation due to the green connotations associated with the process. |
format | Online Article Text |
id | pubmed-8073050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80730502021-04-27 Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin Correa, Rodolpho Fagundes Colucci, Giovana Halla, Noureddine Pinto, João Alves Santamaria-Echart, Arantzazu Blanco, Silvia Priscila Fernandes, Isabel Patrícia Barreiro, Maria Filomena Molecules Article Microencapsulation procedures have recently focused attention on designing novel microspheres via green synthesis strategies. The use of chitosan (CS) as an encapsulating material has increased interest due to its unique bioactive properties and the various crosslinking possibilities offered by their functional groups. The consolidation of the microspheres by physical crosslinking using sodium tripolyphosphate (TPP) combined with chemical crosslinking using vanillin (VA) open new opportunities in the framework of green dual crosslinking strategies. The developed strategy, a straightforward technique based on an aqueous medium avoiding complex separation/washing steps, offers advantages over the processes based on VA, mostly using water-in-oil emulsion approaches. Thus, in this work, the combination of TPP crosslinking (3, 5, and 10 wt.%) via spray-coagulation technique with two VA crosslinking methods (in situ and post-treatment using 1 wt.% VA) were employed in the preparation of microspheres. The microspheres were characterized concerning morphology, particle size, physicochemical properties, thermal stability, and swelling behavior. Results revealed that the combination of 5 wt.% TPP with in situ VA crosslinking led to microspheres with promising properties, being an attractive alternative for natural bioactives encapsulation due to the green connotations associated with the process. MDPI 2021-04-16 /pmc/articles/PMC8073050/ /pubmed/33923713 http://dx.doi.org/10.3390/molecules26082325 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Correa, Rodolpho Fagundes Colucci, Giovana Halla, Noureddine Pinto, João Alves Santamaria-Echart, Arantzazu Blanco, Silvia Priscila Fernandes, Isabel Patrícia Barreiro, Maria Filomena Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin |
title | Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin |
title_full | Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin |
title_fullStr | Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin |
title_full_unstemmed | Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin |
title_short | Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin |
title_sort | development of chitosan microspheres through a green dual crosslinking strategy based on tripolyphosphate and vanillin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073050/ https://www.ncbi.nlm.nih.gov/pubmed/33923713 http://dx.doi.org/10.3390/molecules26082325 |
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