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Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin

Microencapsulation procedures have recently focused attention on designing novel microspheres via green synthesis strategies. The use of chitosan (CS) as an encapsulating material has increased interest due to its unique bioactive properties and the various crosslinking possibilities offered by thei...

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Autores principales: Correa, Rodolpho Fagundes, Colucci, Giovana, Halla, Noureddine, Pinto, João Alves, Santamaria-Echart, Arantzazu, Blanco, Silvia Priscila, Fernandes, Isabel Patrícia, Barreiro, Maria Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073050/
https://www.ncbi.nlm.nih.gov/pubmed/33923713
http://dx.doi.org/10.3390/molecules26082325
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author Correa, Rodolpho Fagundes
Colucci, Giovana
Halla, Noureddine
Pinto, João Alves
Santamaria-Echart, Arantzazu
Blanco, Silvia Priscila
Fernandes, Isabel Patrícia
Barreiro, Maria Filomena
author_facet Correa, Rodolpho Fagundes
Colucci, Giovana
Halla, Noureddine
Pinto, João Alves
Santamaria-Echart, Arantzazu
Blanco, Silvia Priscila
Fernandes, Isabel Patrícia
Barreiro, Maria Filomena
author_sort Correa, Rodolpho Fagundes
collection PubMed
description Microencapsulation procedures have recently focused attention on designing novel microspheres via green synthesis strategies. The use of chitosan (CS) as an encapsulating material has increased interest due to its unique bioactive properties and the various crosslinking possibilities offered by their functional groups. The consolidation of the microspheres by physical crosslinking using sodium tripolyphosphate (TPP) combined with chemical crosslinking using vanillin (VA) open new opportunities in the framework of green dual crosslinking strategies. The developed strategy, a straightforward technique based on an aqueous medium avoiding complex separation/washing steps, offers advantages over the processes based on VA, mostly using water-in-oil emulsion approaches. Thus, in this work, the combination of TPP crosslinking (3, 5, and 10 wt.%) via spray-coagulation technique with two VA crosslinking methods (in situ and post-treatment using 1 wt.% VA) were employed in the preparation of microspheres. The microspheres were characterized concerning morphology, particle size, physicochemical properties, thermal stability, and swelling behavior. Results revealed that the combination of 5 wt.% TPP with in situ VA crosslinking led to microspheres with promising properties, being an attractive alternative for natural bioactives encapsulation due to the green connotations associated with the process.
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spelling pubmed-80730502021-04-27 Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin Correa, Rodolpho Fagundes Colucci, Giovana Halla, Noureddine Pinto, João Alves Santamaria-Echart, Arantzazu Blanco, Silvia Priscila Fernandes, Isabel Patrícia Barreiro, Maria Filomena Molecules Article Microencapsulation procedures have recently focused attention on designing novel microspheres via green synthesis strategies. The use of chitosan (CS) as an encapsulating material has increased interest due to its unique bioactive properties and the various crosslinking possibilities offered by their functional groups. The consolidation of the microspheres by physical crosslinking using sodium tripolyphosphate (TPP) combined with chemical crosslinking using vanillin (VA) open new opportunities in the framework of green dual crosslinking strategies. The developed strategy, a straightforward technique based on an aqueous medium avoiding complex separation/washing steps, offers advantages over the processes based on VA, mostly using water-in-oil emulsion approaches. Thus, in this work, the combination of TPP crosslinking (3, 5, and 10 wt.%) via spray-coagulation technique with two VA crosslinking methods (in situ and post-treatment using 1 wt.% VA) were employed in the preparation of microspheres. The microspheres were characterized concerning morphology, particle size, physicochemical properties, thermal stability, and swelling behavior. Results revealed that the combination of 5 wt.% TPP with in situ VA crosslinking led to microspheres with promising properties, being an attractive alternative for natural bioactives encapsulation due to the green connotations associated with the process. MDPI 2021-04-16 /pmc/articles/PMC8073050/ /pubmed/33923713 http://dx.doi.org/10.3390/molecules26082325 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Correa, Rodolpho Fagundes
Colucci, Giovana
Halla, Noureddine
Pinto, João Alves
Santamaria-Echart, Arantzazu
Blanco, Silvia Priscila
Fernandes, Isabel Patrícia
Barreiro, Maria Filomena
Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin
title Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin
title_full Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin
title_fullStr Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin
title_full_unstemmed Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin
title_short Development of Chitosan Microspheres through a Green Dual Crosslinking Strategy Based on Tripolyphosphate and Vanillin
title_sort development of chitosan microspheres through a green dual crosslinking strategy based on tripolyphosphate and vanillin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073050/
https://www.ncbi.nlm.nih.gov/pubmed/33923713
http://dx.doi.org/10.3390/molecules26082325
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