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Viral Infection Modulates Mitochondrial Function

Mitochondria are important organelles involved in metabolism and programmed cell death in eukaryotic cells. In addition, mitochondria are also closely related to the innate immunity of host cells against viruses. The abnormality of mitochondrial morphology and function might lead to a variety of dis...

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Autores principales: Li, Xiaowen, Wu, Keke, Zeng, Sen, Zhao, Feifan, Fan, Jindai, Li, Zhaoyao, Yi, Lin, Ding, Hongxing, Zhao, Mingqiu, Fan, Shuangqi, Chen, Jinding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073244/
https://www.ncbi.nlm.nih.gov/pubmed/33923929
http://dx.doi.org/10.3390/ijms22084260
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author Li, Xiaowen
Wu, Keke
Zeng, Sen
Zhao, Feifan
Fan, Jindai
Li, Zhaoyao
Yi, Lin
Ding, Hongxing
Zhao, Mingqiu
Fan, Shuangqi
Chen, Jinding
author_facet Li, Xiaowen
Wu, Keke
Zeng, Sen
Zhao, Feifan
Fan, Jindai
Li, Zhaoyao
Yi, Lin
Ding, Hongxing
Zhao, Mingqiu
Fan, Shuangqi
Chen, Jinding
author_sort Li, Xiaowen
collection PubMed
description Mitochondria are important organelles involved in metabolism and programmed cell death in eukaryotic cells. In addition, mitochondria are also closely related to the innate immunity of host cells against viruses. The abnormality of mitochondrial morphology and function might lead to a variety of diseases. A large number of studies have found that a variety of viral infections could change mitochondrial dynamics, mediate mitochondria-induced cell death, and alter the mitochondrial metabolic status and cellular innate immune response to maintain intracellular survival. Meanwhile, mitochondria can also play an antiviral role during viral infection, thereby protecting the host. Therefore, mitochondria play an important role in the interaction between the host and the virus. Herein, we summarize how viral infections affect microbial pathogenesis by altering mitochondrial morphology and function and how viruses escape the host immune response.
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spelling pubmed-80732442021-04-27 Viral Infection Modulates Mitochondrial Function Li, Xiaowen Wu, Keke Zeng, Sen Zhao, Feifan Fan, Jindai Li, Zhaoyao Yi, Lin Ding, Hongxing Zhao, Mingqiu Fan, Shuangqi Chen, Jinding Int J Mol Sci Review Mitochondria are important organelles involved in metabolism and programmed cell death in eukaryotic cells. In addition, mitochondria are also closely related to the innate immunity of host cells against viruses. The abnormality of mitochondrial morphology and function might lead to a variety of diseases. A large number of studies have found that a variety of viral infections could change mitochondrial dynamics, mediate mitochondria-induced cell death, and alter the mitochondrial metabolic status and cellular innate immune response to maintain intracellular survival. Meanwhile, mitochondria can also play an antiviral role during viral infection, thereby protecting the host. Therefore, mitochondria play an important role in the interaction between the host and the virus. Herein, we summarize how viral infections affect microbial pathogenesis by altering mitochondrial morphology and function and how viruses escape the host immune response. MDPI 2021-04-20 /pmc/articles/PMC8073244/ /pubmed/33923929 http://dx.doi.org/10.3390/ijms22084260 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Xiaowen
Wu, Keke
Zeng, Sen
Zhao, Feifan
Fan, Jindai
Li, Zhaoyao
Yi, Lin
Ding, Hongxing
Zhao, Mingqiu
Fan, Shuangqi
Chen, Jinding
Viral Infection Modulates Mitochondrial Function
title Viral Infection Modulates Mitochondrial Function
title_full Viral Infection Modulates Mitochondrial Function
title_fullStr Viral Infection Modulates Mitochondrial Function
title_full_unstemmed Viral Infection Modulates Mitochondrial Function
title_short Viral Infection Modulates Mitochondrial Function
title_sort viral infection modulates mitochondrial function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073244/
https://www.ncbi.nlm.nih.gov/pubmed/33923929
http://dx.doi.org/10.3390/ijms22084260
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