Genistein Activates Transcription Factor EB and Corrects Niemann–Pick C Phenotype

Niemann–Pick type C disease (NPCD) is a lysosomal storage disease (LSD) characterized by abnormal cholesterol accumulation in lysosomes, impaired autophagy flux, and lysosomal dysfunction. The activation of transcription factor EB (TFEB), a master lysosomal function regulator, reduces the accumulati...

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Detalles Bibliográficos
Autores principales: Argüello, Graciela, Balboa, Elisa, Tapia, Pablo J., Castro, Juan, Yañez, María José, Mattar, Pamela, Pulgar, Rodrigo, Zanlungo, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073251/
https://www.ncbi.nlm.nih.gov/pubmed/33921734
http://dx.doi.org/10.3390/ijms22084220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073251/
https://www.ncbi.nlm.nih.gov/pubmed/33921734
http://dx.doi.org/10.3390/ijms22084220

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