Cargando…

Genistein Activates Transcription Factor EB and Corrects Niemann–Pick C Phenotype

Niemann–Pick type C disease (NPCD) is a lysosomal storage disease (LSD) characterized by abnormal cholesterol accumulation in lysosomes, impaired autophagy flux, and lysosomal dysfunction. The activation of transcription factor EB (TFEB), a master lysosomal function regulator, reduces the accumulati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Argüello, Graciela, Balboa, Elisa, Tapia, Pablo J., Castro, Juan, Yañez, María José, Mattar, Pamela, Pulgar, Rodrigo, Zanlungo, Silvana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073251/ https://www.ncbi.nlm.nih.gov/pubmed/33921734 http://dx.doi.org/10.3390/ijms22084220

Ejemplares similares

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease
por: Torres, Sandra, et al.
Publicado: (2017)

Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick Type C Disease
por: Vázquez, Mary Carmen, et al.
Publicado: (2012)

Vitamin E Dietary Supplementation Improves Neurological Symptoms and Decreases c-Abl/p73 Activation in Niemann-Pick C Mice
por: Marín, Tamara, et al.
Publicado: (2014)

Gadolinium Chloride Rescues Niemann–Pick Type C Liver Damage
por: Klein, Andrés D., et al.
Publicado: (2018)

Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage
por: Balboa, Elisa, et al.
Publicado: (2021)

Understanding the phenotypic variability in Niemann-Pick disease type C (NPC): a need for precision medicine
por: Las Heras, Macarena, et al.
Publicado: (2023)

Complement Component C3 Participates in Early Stages of Niemann–Pick C Mouse Liver Damage
por: Klein, Andrés D., et al.
Publicado: (2020)

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease
por: Torres, Sandra, et al.
Publicado: (2016)

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease
por: Marín, Tamara, et al.
Publicado: (2022)

Alteration of Gene Expression Profile in Niemann-Pick Type C Mice Correlates with Tissue Damage and Oxidative Stress
por: Vázquez, Mary C., et al.
Publicado: (2011)

Disruption in Connexin-Based Communication Is Associated with Intracellular Ca(2+) Signal Alterations in Astrocytes from Niemann-Pick Type C Mice
por: Sáez, Pablo J., et al.
Publicado: (2013)

Niemann-Pick Disease: An Approach for Diagnosis in Adulthood
por: Patiño-Escobar, Bonell, et al.
Publicado: (2019)

Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
por: Cabeza, Carolina, et al.
Publicado: (2012)

Niemann-Pick disease type C
por: Vanier, Marie T
Publicado: (2010)

Stem Cells and Niemann Pick Disease
por: Andolina, Marino
Publicado: (2014)

Stem Cells in Niemann-Pick Disease
por: Kim, Sun-Jung, et al.
Publicado: (2008)

Niemann-Pick disease and platelet dysfunction
Publicado: (2012)

Phenotypic expression of swallowing function in Niemann–Pick disease type C1
por: Solomon, Beth I., et al.
Publicado: (2022)

The prognostic value of Niemann-Pick C1-like protein 1 and Niemann-Pick disease type C2 in hepatocellular carcinoma
por: Chen, Ke-Ji, et al.
Publicado: (2018)

Clinical disease characteristics of patients with Niemann-Pick Disease Type C: findings from the International Niemann-Pick Disease Registry (INPDR)
por: Bolton, Shaun C., et al.
Publicado: (2022)

Clear Cell Chondrosarcoma in Association With Niemann-Pick Disease
por: Srikanth, K. N., et al.
Publicado: (2005)

Immune dysfunction in Niemann‐Pick disease type C
por: Platt, Nick, et al.
Publicado: (2015)

Anesthetic Management in a Child With Niemann-Pick Disease
por: Espahbodi, Ebrahim, et al.
Publicado: (2016)

Niemann-Pick Disease: An Underdiagnosed Lysosomal Storage Disorder
por: Panigrahi, Inusha, et al.
Publicado: (2019)

A calcium message for Niemann-Pick type C
por: Cologna, Stephanie M.
Publicado: (2019)

Treatment trials in Niemann-Pick type C disease
por: Sitarska, Dominika, et al.
Publicado: (2021)

Niemann Pick C disease: lessons from zebrafish development
Publicado: (2011)

Intestinal and Hepatic Niemann-Pick C1-Like 1
por: Park, Sung-Woo
Publicado: (2013)

Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
por: Lopez, Manuel E, et al.
Publicado: (2012)

Efficacy and ototoxicity of different cyclodextrins in Niemann–Pick C disease
por: Davidson, Cristin D., et al.
Publicado: (2016)

Genome sequencing in a case of Niemann–Pick type C
por: Dougherty, Max, et al.
Publicado: (2016)

Niemann-Pick Diseases: The Largest Iranian Cohort with Genetic Analysis
por: Hashemian, Somayyeh, et al.
Publicado: (2019)

Retinal axonal degeneration in Niemann–Pick type C disease
por: Havla, Joachim, et al.
Publicado: (2020)

Mechanistic convergence and shared therapeutic targets in Niemann‐Pick disease
por: Colaco, Alexandria, et al.
Publicado: (2019)

Estimated prevalence of Niemann–Pick type C disease in Quebec
por: Labrecque, Marjorie, et al.
Publicado: (2021)

Spectrum of Movement Disorders in Niemann-Pick Disease Type C
por: Devaraj, Rashmi, et al.
Publicado: (2022)

Niemann-Pick Disease: A Case Report and Literature Review
por: Vélez Pinos, Paola Jacqueline, et al.
Publicado: (2023)

Longitudinal MEMRI analysis of brain phenotypes in a mouse model of Niemann-Pick Type C disease
por: Rallapalli, Harikrishna, et al.
Publicado: (2020)

Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype
por: Piccoli, Elena, et al.
Publicado: (2011)

Phenotype assessment for neurodegenerative murine models with ataxia and application to Niemann–Pick disease, type C1
por: Yerger, Julia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ler6921vhqvmogeni347lgn3pq