Profiling of Adipose and Skeletal Muscle in Human Pancreatic Cancer Cachexia Reveals Distinct Gene Profiles with Convergent Pathways

SIMPLE SUMMARY: More than 80% of patients with pancreatic ductal adenocarcinoma (PDAC) suffer cachexia, characterized by loss of muscle and fat. However, most cachexia studies were predominantly focused on muscle. Our clinical study showed adipose tissue loss as a prognosticator in PDAC cachexia. Ou...

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Detalles Bibliográficos
Autores principales: Narasimhan, Ashok, Zhong, Xiaoling, Au, Ernie P., Ceppa, Eugene P., Nakeeb, Atilla, House, Michael G., Zyromski, Nicholas J., Schmidt, C. Max, Schloss, Katheryn N. H., Schloss, Daniel E. I., Liu, Yunlong, Jiang, Guanglong, Hancock, Bradley A., Radovich, Milan, Kays, Joshua K., Shahda, Safi, Couch, Marion E., Koniaris, Leonidas G., Zimmers, Teresa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073275/
https://www.ncbi.nlm.nih.gov/pubmed/33923976
http://dx.doi.org/10.3390/cancers13081975

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