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Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial

Backgrounds: Social cognition is defined as the mental operations underlying social behavior. Patients with schizophrenia elicit impairments of social cognition, which is linked to poor real-world functional outcomes. In a previous study, transcranial direct current stimulation (tDCS) improved emoti...

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Autores principales: Yamada, Yuji, Inagawa, Takuma, Yokoi, Yuma, Shirama, Aya, Sueyoshi, Kazuki, Wada, Ayumu, Hirabayashi, Naotsugu, Oi, Hideki, Sumiyoshi, Tomiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073289/
https://www.ncbi.nlm.nih.gov/pubmed/33921706
http://dx.doi.org/10.3390/jpm11040317
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author Yamada, Yuji
Inagawa, Takuma
Yokoi, Yuma
Shirama, Aya
Sueyoshi, Kazuki
Wada, Ayumu
Hirabayashi, Naotsugu
Oi, Hideki
Sumiyoshi, Tomiki
author_facet Yamada, Yuji
Inagawa, Takuma
Yokoi, Yuma
Shirama, Aya
Sueyoshi, Kazuki
Wada, Ayumu
Hirabayashi, Naotsugu
Oi, Hideki
Sumiyoshi, Tomiki
author_sort Yamada, Yuji
collection PubMed
description Backgrounds: Social cognition is defined as the mental operations underlying social behavior. Patients with schizophrenia elicit impairments of social cognition, which is linked to poor real-world functional outcomes. In a previous study, transcranial direct current stimulation (tDCS) improved emotional recognition, a domain of social cognition, in patients with schizophrenia. However, since social cognition was only minimally improved by tDCS when administered on frontal brain areas, investigations on the effect of tDCS on other cortical sites more directly related to social cognition are needed. Therefore, we present a study protocol to determine whether multi-session tDCS on superior temporal sulcus (STS) would improve social cognition deficits of schizophrenia. Methods: This is an open-label, single-arm trial, whose objective is to investigate the efficacy and safety of multi-session tDCS over the left STS to improve social cognition in patients with schizophrenia. The primary outcome measure will be the Social Cognition Screening Questionnaire. Neurocognition, functional capacity, and psychotic symptoms will also be evaluated by the Brief Assessment of Cognition in Schizophrenia, UCSD Performance-Based Skills Assessment-Brief, and Positive and Negative Syndrome Scale, respectively. Data will be collected at baseline, and 4 weeks after the end of intervention. If social cognition is improved in patients with schizophrenia by tDCS based on this protocol, we may plan randomized controlled trial.
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spelling pubmed-80732892021-04-27 Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial Yamada, Yuji Inagawa, Takuma Yokoi, Yuma Shirama, Aya Sueyoshi, Kazuki Wada, Ayumu Hirabayashi, Naotsugu Oi, Hideki Sumiyoshi, Tomiki J Pers Med Study Protocol Backgrounds: Social cognition is defined as the mental operations underlying social behavior. Patients with schizophrenia elicit impairments of social cognition, which is linked to poor real-world functional outcomes. In a previous study, transcranial direct current stimulation (tDCS) improved emotional recognition, a domain of social cognition, in patients with schizophrenia. However, since social cognition was only minimally improved by tDCS when administered on frontal brain areas, investigations on the effect of tDCS on other cortical sites more directly related to social cognition are needed. Therefore, we present a study protocol to determine whether multi-session tDCS on superior temporal sulcus (STS) would improve social cognition deficits of schizophrenia. Methods: This is an open-label, single-arm trial, whose objective is to investigate the efficacy and safety of multi-session tDCS over the left STS to improve social cognition in patients with schizophrenia. The primary outcome measure will be the Social Cognition Screening Questionnaire. Neurocognition, functional capacity, and psychotic symptoms will also be evaluated by the Brief Assessment of Cognition in Schizophrenia, UCSD Performance-Based Skills Assessment-Brief, and Positive and Negative Syndrome Scale, respectively. Data will be collected at baseline, and 4 weeks after the end of intervention. If social cognition is improved in patients with schizophrenia by tDCS based on this protocol, we may plan randomized controlled trial. MDPI 2021-04-19 /pmc/articles/PMC8073289/ /pubmed/33921706 http://dx.doi.org/10.3390/jpm11040317 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Study Protocol
Yamada, Yuji
Inagawa, Takuma
Yokoi, Yuma
Shirama, Aya
Sueyoshi, Kazuki
Wada, Ayumu
Hirabayashi, Naotsugu
Oi, Hideki
Sumiyoshi, Tomiki
Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial
title Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial
title_full Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial
title_fullStr Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial
title_full_unstemmed Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial
title_short Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial
title_sort efficacy and safety of multi-session transcranial direct current stimulation on social cognition in schizophrenia: a study protocol for an open-label, single-arm trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073289/
https://www.ncbi.nlm.nih.gov/pubmed/33921706
http://dx.doi.org/10.3390/jpm11040317
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