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Synthesis of New Amino—β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles

New water soluble amino β-cyclodextrin-based polymer was synthesized by reaction between amino cyclodextrin derivatives and pyromellitic anhydride. This experiment presents amino derivatives, which were synthesized by attaching amino groups to β-cyclodextrins (β-CDs) used mono-6-azido-6-deoxy-β-cycl...

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Autores principales: Kozieł, Kinga, Łagiewka, Jakub, Girek, Beata, Folentarska, Agnieszka, Girek, Tomasz, Ciesielski, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073293/
https://www.ncbi.nlm.nih.gov/pubmed/33921681
http://dx.doi.org/10.3390/polym13081332
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author Kozieł, Kinga
Łagiewka, Jakub
Girek, Beata
Folentarska, Agnieszka
Girek, Tomasz
Ciesielski, Wojciech
author_facet Kozieł, Kinga
Łagiewka, Jakub
Girek, Beata
Folentarska, Agnieszka
Girek, Tomasz
Ciesielski, Wojciech
author_sort Kozieł, Kinga
collection PubMed
description New water soluble amino β-cyclodextrin-based polymer was synthesized by reaction between amino cyclodextrin derivatives and pyromellitic anhydride. This experiment presents amino derivatives, which were synthesized by attaching amino groups to β-cyclodextrins (β-CDs) used mono-6-azido-6-deoxy-β-cyclodextrin (β-CD-N(3)) and triphenylphosphine (Ph(3)P) in anhydrous N,N-dimethylformamide (DMF). An amino blocking reaction was conducted. The obtained polymer was purified by ultrafiltration. In addition, an attempt was made to create nanospheres by encapsulating the polymer with chitosan (CT) in an acidic condition. For the first time, nanospheres were obtained in the reaction between an amino β-cyclodextrin polymer and chitosan. Scanning electron microscopy (SEM). (1)H NMR and ESI-MS methods for confirmation of reaction product and for structural characterization were employed. The differential scanning calorimetry (DSC) studies of polymers were also carried out.
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spelling pubmed-80732932021-04-27 Synthesis of New Amino—β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles Kozieł, Kinga Łagiewka, Jakub Girek, Beata Folentarska, Agnieszka Girek, Tomasz Ciesielski, Wojciech Polymers (Basel) Article New water soluble amino β-cyclodextrin-based polymer was synthesized by reaction between amino cyclodextrin derivatives and pyromellitic anhydride. This experiment presents amino derivatives, which were synthesized by attaching amino groups to β-cyclodextrins (β-CDs) used mono-6-azido-6-deoxy-β-cyclodextrin (β-CD-N(3)) and triphenylphosphine (Ph(3)P) in anhydrous N,N-dimethylformamide (DMF). An amino blocking reaction was conducted. The obtained polymer was purified by ultrafiltration. In addition, an attempt was made to create nanospheres by encapsulating the polymer with chitosan (CT) in an acidic condition. For the first time, nanospheres were obtained in the reaction between an amino β-cyclodextrin polymer and chitosan. Scanning electron microscopy (SEM). (1)H NMR and ESI-MS methods for confirmation of reaction product and for structural characterization were employed. The differential scanning calorimetry (DSC) studies of polymers were also carried out. MDPI 2021-04-19 /pmc/articles/PMC8073293/ /pubmed/33921681 http://dx.doi.org/10.3390/polym13081332 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kozieł, Kinga
Łagiewka, Jakub
Girek, Beata
Folentarska, Agnieszka
Girek, Tomasz
Ciesielski, Wojciech
Synthesis of New Amino—β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles
title Synthesis of New Amino—β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles
title_full Synthesis of New Amino—β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles
title_fullStr Synthesis of New Amino—β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles
title_full_unstemmed Synthesis of New Amino—β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles
title_short Synthesis of New Amino—β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles
title_sort synthesis of new amino—β-cyclodextrin polymer, cross-linked with pyromellitic dianhydride and their use for the synthesis of polymeric cyclodextrin based nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073293/
https://www.ncbi.nlm.nih.gov/pubmed/33921681
http://dx.doi.org/10.3390/polym13081332
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