Cargando…
BK(Ca) Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia
This study explored whether KMUP-1 improved chronic constriction injury (CCI)-induced BK(Ca) current inhibition in dorsal root ganglion (DRG) neurons. Rats were randomly assigned to four groups: sham, sham + KMUP-1, CCI, and CCI + KMUP-1 (5 mg/kg/day, i.p.). DRG neuronal cells (L4–L6) were isolated...
Autores principales: | Cheng, Kuang-I, Yang, Kan-Ting, Kung, Chien-Lun, Cheng, Yu-Chi, Yeh, Jwu-Lai, Dai, Zen-Kong, Wu, Bin-Nan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073306/ https://www.ncbi.nlm.nih.gov/pubmed/33923953 http://dx.doi.org/10.3390/cells10040949 |
Ejemplares similares
-
Xanthine Derivative KMUP-1 Attenuates Experimental Periodontitis by Reducing Osteoclast Differentiation and Inflammation
por: Kuo, Cheng-Hsiang, et al.
Publicado: (2022) -
The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K(+)-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries
por: Dai, Zen-Kong, et al.
Publicado: (2015) -
Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice
por: Lai, Chao-Han, et al.
Publicado: (2020) -
In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis
por: Huang, Shang-En, et al.
Publicado: (2021) -
KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways
por: Lee, Meng-Luen, et al.
Publicado: (2019)