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Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model
(1) Background: Optimal initial oxygen (O(2)) concentration in preterm neonates is controversial. Our objectives were to compare the effect of delayed cord clamping with ventilation (DCCV) to early cord clamping followed by ventilation (ECCV) on O(2) exposure, gas exchange, and hemodynamics in an as...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073339/ https://www.ncbi.nlm.nih.gov/pubmed/33920664 http://dx.doi.org/10.3390/children8040307 |
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author | Chandrasekharan, Praveen Gugino, Sylvia Helman, Justin Koenigsknecht, Carmon Nielsen, Lori Bradley, Nicole Nair, Jayasree Agrawal, Vikash Bawa, Mausma Mari, Andreina Rawat, Munmun Lakshminrusimha, Satyan |
author_facet | Chandrasekharan, Praveen Gugino, Sylvia Helman, Justin Koenigsknecht, Carmon Nielsen, Lori Bradley, Nicole Nair, Jayasree Agrawal, Vikash Bawa, Mausma Mari, Andreina Rawat, Munmun Lakshminrusimha, Satyan |
author_sort | Chandrasekharan, Praveen |
collection | PubMed |
description | (1) Background: Optimal initial oxygen (O(2)) concentration in preterm neonates is controversial. Our objectives were to compare the effect of delayed cord clamping with ventilation (DCCV) to early cord clamping followed by ventilation (ECCV) on O(2) exposure, gas exchange, and hemodynamics in an asphyxiated preterm ovine model. (2) Methods: Asphyxiated preterm lambs (127–128 d) with heart rate <90 bpm were randomly assigned to DCCV or ECCV. In DCCV, positive pressure ventilation (PPV) was initiated with 30–60% O(2) and titrated based on preductal saturations (SpO(2)) with an intact cord for 5 min, followed by clamping. In ECCV, the cord was clamped, and PPV was initiated. (3) Results: Fifteen asphyxiated preterm lambs were randomized to DCCV (N = 7) or ECCV (N = 8). The inspired O(2) (40 ± 20% vs. 60 ± 20%, p < 0.05) and oxygen load (520 (IQR 414–530) vs. 775 (IQR 623–868), p-0.03) in the DCCV group were significantly lower than ECCV. Arterial oxygenation and carbon dioxide (PaCO(2)) levels were significantly lower and peak pulmonary blood flow was higher with DCCV. (4) Conclusion: In asphyxiated preterm lambs, resuscitation with an intact cord decreased O(2) exposure load improved ventilation with an increase in peak pulmonary blood flow in the first 5 min. |
format | Online Article Text |
id | pubmed-8073339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80733392021-04-27 Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model Chandrasekharan, Praveen Gugino, Sylvia Helman, Justin Koenigsknecht, Carmon Nielsen, Lori Bradley, Nicole Nair, Jayasree Agrawal, Vikash Bawa, Mausma Mari, Andreina Rawat, Munmun Lakshminrusimha, Satyan Children (Basel) Article (1) Background: Optimal initial oxygen (O(2)) concentration in preterm neonates is controversial. Our objectives were to compare the effect of delayed cord clamping with ventilation (DCCV) to early cord clamping followed by ventilation (ECCV) on O(2) exposure, gas exchange, and hemodynamics in an asphyxiated preterm ovine model. (2) Methods: Asphyxiated preterm lambs (127–128 d) with heart rate <90 bpm were randomly assigned to DCCV or ECCV. In DCCV, positive pressure ventilation (PPV) was initiated with 30–60% O(2) and titrated based on preductal saturations (SpO(2)) with an intact cord for 5 min, followed by clamping. In ECCV, the cord was clamped, and PPV was initiated. (3) Results: Fifteen asphyxiated preterm lambs were randomized to DCCV (N = 7) or ECCV (N = 8). The inspired O(2) (40 ± 20% vs. 60 ± 20%, p < 0.05) and oxygen load (520 (IQR 414–530) vs. 775 (IQR 623–868), p-0.03) in the DCCV group were significantly lower than ECCV. Arterial oxygenation and carbon dioxide (PaCO(2)) levels were significantly lower and peak pulmonary blood flow was higher with DCCV. (4) Conclusion: In asphyxiated preterm lambs, resuscitation with an intact cord decreased O(2) exposure load improved ventilation with an increase in peak pulmonary blood flow in the first 5 min. MDPI 2021-04-17 /pmc/articles/PMC8073339/ /pubmed/33920664 http://dx.doi.org/10.3390/children8040307 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chandrasekharan, Praveen Gugino, Sylvia Helman, Justin Koenigsknecht, Carmon Nielsen, Lori Bradley, Nicole Nair, Jayasree Agrawal, Vikash Bawa, Mausma Mari, Andreina Rawat, Munmun Lakshminrusimha, Satyan Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model |
title | Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model |
title_full | Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model |
title_fullStr | Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model |
title_full_unstemmed | Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model |
title_short | Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model |
title_sort | resuscitation with an intact cord enhances pulmonary vasodilation and ventilation with reduction in systemic oxygen exposure and oxygen load in an asphyxiated preterm ovine model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073339/ https://www.ncbi.nlm.nih.gov/pubmed/33920664 http://dx.doi.org/10.3390/children8040307 |
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