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The Role of Macrophages in Cancer Development and Therapy
SIMPLE SUMMARY: Tumor-Associated Macrophages (TAMs) play an important role in the development of tumors, modulation of neoangiogenesis, immune suppression, and metastasis. High infiltration of macrophages in the tumor is also correlated with poor prognosis in several cancer types. Therefore, they be...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073377/ https://www.ncbi.nlm.nih.gov/pubmed/33919517 http://dx.doi.org/10.3390/cancers13081946 |
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author | Cendrowicz, Ewa Sas, Zuzanna Bremer, Edwin Rygiel, Tomasz P. |
author_facet | Cendrowicz, Ewa Sas, Zuzanna Bremer, Edwin Rygiel, Tomasz P. |
author_sort | Cendrowicz, Ewa |
collection | PubMed |
description | SIMPLE SUMMARY: Tumor-Associated Macrophages (TAMs) play an important role in the development of tumors, modulation of neoangiogenesis, immune suppression, and metastasis. High infiltration of macrophages in the tumor is also correlated with poor prognosis in several cancer types. Therefore, they became an attractive target for cancer immunotherapies. In this review, we describe the role of macrophages in tumorigenesis and summarize the most recent advances in the therapies targeting TAMs. ABSTRACT: Macrophages are critical mediators of tissue homeostasis and influence various aspects of immunity. Tumor-associated macrophages are one of the main cellular components of the tumor microenvironment. Depending on their activation status, macrophages can exert a dual influence on tumorigenesis by either antagonizing the cytotoxic activity of immune cells or, less frequently, by enhancing antitumor responses. In most situations, TAMs suppress T cell recruitment and function or regulate other aspects of tumor immunity. The importance of TAMs targeting in cancer therapy is derived from the strong association between the high infiltration of TAMs in the tumor tissue with poor patient prognosis. Several macrophage-targeting approaches in anticancer therapy are developed, including TAM depletion, inhibition of new TAM differentiation, or re-education of TAM activation for cancer cell phagocytosis. In this review, we will describe the role of TAMs in tumor development, including such aspects as protumorigenic inflammation, immune suppression, neoangiogenesis, and enhancement of tissue invasion and distant metastasis. Furthermore, we will discuss therapeutic approaches that aim to deplete TAMs or, on the contrary, re-educate TAMs for cancer cell phagocytosis and antitumor immunity. |
format | Online Article Text |
id | pubmed-8073377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80733772021-04-27 The Role of Macrophages in Cancer Development and Therapy Cendrowicz, Ewa Sas, Zuzanna Bremer, Edwin Rygiel, Tomasz P. Cancers (Basel) Review SIMPLE SUMMARY: Tumor-Associated Macrophages (TAMs) play an important role in the development of tumors, modulation of neoangiogenesis, immune suppression, and metastasis. High infiltration of macrophages in the tumor is also correlated with poor prognosis in several cancer types. Therefore, they became an attractive target for cancer immunotherapies. In this review, we describe the role of macrophages in tumorigenesis and summarize the most recent advances in the therapies targeting TAMs. ABSTRACT: Macrophages are critical mediators of tissue homeostasis and influence various aspects of immunity. Tumor-associated macrophages are one of the main cellular components of the tumor microenvironment. Depending on their activation status, macrophages can exert a dual influence on tumorigenesis by either antagonizing the cytotoxic activity of immune cells or, less frequently, by enhancing antitumor responses. In most situations, TAMs suppress T cell recruitment and function or regulate other aspects of tumor immunity. The importance of TAMs targeting in cancer therapy is derived from the strong association between the high infiltration of TAMs in the tumor tissue with poor patient prognosis. Several macrophage-targeting approaches in anticancer therapy are developed, including TAM depletion, inhibition of new TAM differentiation, or re-education of TAM activation for cancer cell phagocytosis. In this review, we will describe the role of TAMs in tumor development, including such aspects as protumorigenic inflammation, immune suppression, neoangiogenesis, and enhancement of tissue invasion and distant metastasis. Furthermore, we will discuss therapeutic approaches that aim to deplete TAMs or, on the contrary, re-educate TAMs for cancer cell phagocytosis and antitumor immunity. MDPI 2021-04-18 /pmc/articles/PMC8073377/ /pubmed/33919517 http://dx.doi.org/10.3390/cancers13081946 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cendrowicz, Ewa Sas, Zuzanna Bremer, Edwin Rygiel, Tomasz P. The Role of Macrophages in Cancer Development and Therapy |
title | The Role of Macrophages in Cancer Development and Therapy |
title_full | The Role of Macrophages in Cancer Development and Therapy |
title_fullStr | The Role of Macrophages in Cancer Development and Therapy |
title_full_unstemmed | The Role of Macrophages in Cancer Development and Therapy |
title_short | The Role of Macrophages in Cancer Development and Therapy |
title_sort | role of macrophages in cancer development and therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073377/ https://www.ncbi.nlm.nih.gov/pubmed/33919517 http://dx.doi.org/10.3390/cancers13081946 |
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