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Increased Creatine Kinase May Predict A Worse COVID-19 Outcome
Early reports from Asia suggested that increased serum levels of the muscular enzyme creatine-(phospho)-kinase (CK/CPK) could be associated with a more severe prognosis in COVID-19. The aim of this single-center retrospective cohort study of 331 consecutive COVID-19 patients who were hospitalized du...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073399/ https://www.ncbi.nlm.nih.gov/pubmed/33923719 http://dx.doi.org/10.3390/jcm10081734 |
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author | Orsucci, Daniele Trezzi, Michele Anichini, Roberto Blanc, Pierluigi Barontini, Leandro Biagini, Carlo Capitanini, Alessandro Comeglio, Marco Corsini, Paulo Gemignani, Federico Giannecchini, Roberto Giusti, Massimo Lombardi, Mario Marrucci, Elena Natali, Alessandro Nenci, Gabriele Vannucci, Franco Volpi, Gino |
author_facet | Orsucci, Daniele Trezzi, Michele Anichini, Roberto Blanc, Pierluigi Barontini, Leandro Biagini, Carlo Capitanini, Alessandro Comeglio, Marco Corsini, Paulo Gemignani, Federico Giannecchini, Roberto Giusti, Massimo Lombardi, Mario Marrucci, Elena Natali, Alessandro Nenci, Gabriele Vannucci, Franco Volpi, Gino |
author_sort | Orsucci, Daniele |
collection | PubMed |
description | Early reports from Asia suggested that increased serum levels of the muscular enzyme creatine-(phospho)-kinase (CK/CPK) could be associated with a more severe prognosis in COVID-19. The aim of this single-center retrospective cohort study of 331 consecutive COVID-19 patients who were hospitalized during Italy’s “first wave” was to verify this relationship, and to evaluate the role of possible confounding factors (age, body mass index, gender, and comorbidities). We subdivided our cohort in two groups, based on “severe” (n = 99) or “mild” (n = 232) outcomes. “Severe” disease is defined here as death and/or mechanical invasive ventilation, in contrast to “mild” patients, who were discharged alive with no need for invasive ventilation; this latter group could also include those patients who were treated with non-invasive ventilation. The CK levels at admission were higher in those subjects who later experienced more severe outcomes (median, 126; range, 10–1672 U/L, versus median, 82; range, 12–1499 U/L, p = 0.01), and hyperCKemia >200 U/L was associated with a worse prognosis. Regression analysis confirmed that increased CK acted as an independent predictor for a “severe” outcome. HyperCKemia was generally transient, returning to normal during hospitalization in the majority of both “severe” and “mild” patients. Although the direct infection of voluntary muscle is unproven, transient muscular dysfunction is common during the course of COVID-19. The influence of this novel coronavirus on voluntary muscle really needs to be clarified. |
format | Online Article Text |
id | pubmed-8073399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80733992021-04-27 Increased Creatine Kinase May Predict A Worse COVID-19 Outcome Orsucci, Daniele Trezzi, Michele Anichini, Roberto Blanc, Pierluigi Barontini, Leandro Biagini, Carlo Capitanini, Alessandro Comeglio, Marco Corsini, Paulo Gemignani, Federico Giannecchini, Roberto Giusti, Massimo Lombardi, Mario Marrucci, Elena Natali, Alessandro Nenci, Gabriele Vannucci, Franco Volpi, Gino J Clin Med Article Early reports from Asia suggested that increased serum levels of the muscular enzyme creatine-(phospho)-kinase (CK/CPK) could be associated with a more severe prognosis in COVID-19. The aim of this single-center retrospective cohort study of 331 consecutive COVID-19 patients who were hospitalized during Italy’s “first wave” was to verify this relationship, and to evaluate the role of possible confounding factors (age, body mass index, gender, and comorbidities). We subdivided our cohort in two groups, based on “severe” (n = 99) or “mild” (n = 232) outcomes. “Severe” disease is defined here as death and/or mechanical invasive ventilation, in contrast to “mild” patients, who were discharged alive with no need for invasive ventilation; this latter group could also include those patients who were treated with non-invasive ventilation. The CK levels at admission were higher in those subjects who later experienced more severe outcomes (median, 126; range, 10–1672 U/L, versus median, 82; range, 12–1499 U/L, p = 0.01), and hyperCKemia >200 U/L was associated with a worse prognosis. Regression analysis confirmed that increased CK acted as an independent predictor for a “severe” outcome. HyperCKemia was generally transient, returning to normal during hospitalization in the majority of both “severe” and “mild” patients. Although the direct infection of voluntary muscle is unproven, transient muscular dysfunction is common during the course of COVID-19. The influence of this novel coronavirus on voluntary muscle really needs to be clarified. MDPI 2021-04-16 /pmc/articles/PMC8073399/ /pubmed/33923719 http://dx.doi.org/10.3390/jcm10081734 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Orsucci, Daniele Trezzi, Michele Anichini, Roberto Blanc, Pierluigi Barontini, Leandro Biagini, Carlo Capitanini, Alessandro Comeglio, Marco Corsini, Paulo Gemignani, Federico Giannecchini, Roberto Giusti, Massimo Lombardi, Mario Marrucci, Elena Natali, Alessandro Nenci, Gabriele Vannucci, Franco Volpi, Gino Increased Creatine Kinase May Predict A Worse COVID-19 Outcome |
title | Increased Creatine Kinase May Predict A Worse COVID-19 Outcome |
title_full | Increased Creatine Kinase May Predict A Worse COVID-19 Outcome |
title_fullStr | Increased Creatine Kinase May Predict A Worse COVID-19 Outcome |
title_full_unstemmed | Increased Creatine Kinase May Predict A Worse COVID-19 Outcome |
title_short | Increased Creatine Kinase May Predict A Worse COVID-19 Outcome |
title_sort | increased creatine kinase may predict a worse covid-19 outcome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073399/ https://www.ncbi.nlm.nih.gov/pubmed/33923719 http://dx.doi.org/10.3390/jcm10081734 |
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