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Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management

Care management of newborns in the neonatal intensive care unit (NICU) requires numerous PVC (PolyVinyl Chloride) medical devices (MD) containing plasticizers that can migrate and contaminate the patient. We measured the magnitude of neonates’ exposure to plasticizers (di-ethylhexylphthalate (DEHP)...

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Autores principales: Bernard, Lise, Bouattour, Yassine, Masse, Morgane, Boeuf, Benoît, Decaudin, Bertrand, Genay, Stéphanie, Lambert, Céline, Moreau, Emmanuel, Pereira, Bruno, Pinguet, Jérémy, Richard, Damien, Sautou, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073472/
https://www.ncbi.nlm.nih.gov/pubmed/33921860
http://dx.doi.org/10.3390/metabo11040252
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author Bernard, Lise
Bouattour, Yassine
Masse, Morgane
Boeuf, Benoît
Decaudin, Bertrand
Genay, Stéphanie
Lambert, Céline
Moreau, Emmanuel
Pereira, Bruno
Pinguet, Jérémy
Richard, Damien
Sautou, Valérie
author_facet Bernard, Lise
Bouattour, Yassine
Masse, Morgane
Boeuf, Benoît
Decaudin, Bertrand
Genay, Stéphanie
Lambert, Céline
Moreau, Emmanuel
Pereira, Bruno
Pinguet, Jérémy
Richard, Damien
Sautou, Valérie
author_sort Bernard, Lise
collection PubMed
description Care management of newborns in the neonatal intensive care unit (NICU) requires numerous PVC (PolyVinyl Chloride) medical devices (MD) containing plasticizers that can migrate and contaminate the patient. We measured the magnitude of neonates’ exposure to plasticizers (di-ethylhexylphthalate (DEHP) and alternatives) in relation to urinary concentrations of their metabolites. Plasticizers’ exposure was evaluated (1) by calculating the amounts of plasticizers prone to be released from each MD used for care management, and (2) by measuring the patients’ urinary levels of each plasticizers’ metabolites. 104 neonates were enrolled. They were exposed to di-isononylphthalate (DINP), especially via transfusion and infusion MD, and to DEHP via ECMO (Extra Corporeal Membrane Oxygenation) and respiratory assistance MD. Mean exposure doses exceeded the derived no-effect level of DINP and DEHP by a 10-fold and a 1000-fold factor. No PVC MD were plasticized with di-isononylcyclohexane-1,2-dicarboxylate (DINCH). High urinary concentrations of DEHP metabolites were directly correlated with DEHP exposure through ECMO MD. Urinary concentrations of DINP metabolites in transfused patients were also high. DINCH metabolites were found in urine, suggesting another route of exposure. Neonates in NICU are considerably exposed to plasticizers, with magnitudes varying with the type of MD used. The high exposure to DEHP and DINP leads to a risk of their metabolites’ toxicity.
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spelling pubmed-80734722021-04-27 Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management Bernard, Lise Bouattour, Yassine Masse, Morgane Boeuf, Benoît Decaudin, Bertrand Genay, Stéphanie Lambert, Céline Moreau, Emmanuel Pereira, Bruno Pinguet, Jérémy Richard, Damien Sautou, Valérie Metabolites Article Care management of newborns in the neonatal intensive care unit (NICU) requires numerous PVC (PolyVinyl Chloride) medical devices (MD) containing plasticizers that can migrate and contaminate the patient. We measured the magnitude of neonates’ exposure to plasticizers (di-ethylhexylphthalate (DEHP) and alternatives) in relation to urinary concentrations of their metabolites. Plasticizers’ exposure was evaluated (1) by calculating the amounts of plasticizers prone to be released from each MD used for care management, and (2) by measuring the patients’ urinary levels of each plasticizers’ metabolites. 104 neonates were enrolled. They were exposed to di-isononylphthalate (DINP), especially via transfusion and infusion MD, and to DEHP via ECMO (Extra Corporeal Membrane Oxygenation) and respiratory assistance MD. Mean exposure doses exceeded the derived no-effect level of DINP and DEHP by a 10-fold and a 1000-fold factor. No PVC MD were plasticized with di-isononylcyclohexane-1,2-dicarboxylate (DINCH). High urinary concentrations of DEHP metabolites were directly correlated with DEHP exposure through ECMO MD. Urinary concentrations of DINP metabolites in transfused patients were also high. DINCH metabolites were found in urine, suggesting another route of exposure. Neonates in NICU are considerably exposed to plasticizers, with magnitudes varying with the type of MD used. The high exposure to DEHP and DINP leads to a risk of their metabolites’ toxicity. MDPI 2021-04-19 /pmc/articles/PMC8073472/ /pubmed/33921860 http://dx.doi.org/10.3390/metabo11040252 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bernard, Lise
Bouattour, Yassine
Masse, Morgane
Boeuf, Benoît
Decaudin, Bertrand
Genay, Stéphanie
Lambert, Céline
Moreau, Emmanuel
Pereira, Bruno
Pinguet, Jérémy
Richard, Damien
Sautou, Valérie
Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management
title Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management
title_full Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management
title_fullStr Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management
title_full_unstemmed Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management
title_short Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management
title_sort association between urinary metabolites and the exposure of intensive care newborns to plasticizers of medical devices used for their care management
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073472/
https://www.ncbi.nlm.nih.gov/pubmed/33921860
http://dx.doi.org/10.3390/metabo11040252
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