A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

BACKGROUND: Heart rate follows a diurnal variation, and slow heart rhythms occur primarily at night. OBJECTIVE: The lower heart rate during sleep is assumed to be neural in origin, but here we tested whether a day-night difference in intrinsic pacemaking is involved. METHODS: In vivo and in vitro el...

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Detalles Bibliográficos
Autores principales: D’Souza, Alicia, Wang, Yanwen, Anderson, Cali, Bucchi, Annalisa, Baruscotti, Mirko, Olieslagers, Servé, Mesirca, Pietro, Johnsen, Anne Berit, Mastitskaya, Svetlana, Ni, Haibo, Zhang, Yu, Black, Nicholas, Cox, Charlotte, Wegner, Sven, Bano-Otalora, Beatriz, Petit, Cheryl, Gill, Eleanor, Logantha, Sunil Jit R.J., Dobrzynski, Halina, Ashton, Nick, Hart, George, Zhang, Rai, Zhang, Henggui, Cartwright, Elizabeth J., Wisloff, Ulrik, Mangoni, Matteo E., da Costa Martins, Paula A., Piggins, Hugh D., DiFrancesco, Dario, Boyett, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Experimental
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073545/
https://www.ncbi.nlm.nih.gov/pubmed/33278629
http://dx.doi.org/10.1016/j.hrthm.2020.11.026

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