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Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies
The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity again...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073650/ https://www.ncbi.nlm.nih.gov/pubmed/33921908 http://dx.doi.org/10.3390/molecules26082382 |
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author | Mirzaei, Sepideh Hushmandi, Kiavash Zabolian, Amirhossein Saleki, Hossein Torabi, Seyed Mohammad Reza Ranjbar, Adnan SeyedSaleh, SeyedHesam Sharifzadeh, Seyed Omid Khan, Haroon Ashrafizadeh, Milad Zarrabi, Ali Ahn, Kwang-seok |
author_facet | Mirzaei, Sepideh Hushmandi, Kiavash Zabolian, Amirhossein Saleki, Hossein Torabi, Seyed Mohammad Reza Ranjbar, Adnan SeyedSaleh, SeyedHesam Sharifzadeh, Seyed Omid Khan, Haroon Ashrafizadeh, Milad Zarrabi, Ali Ahn, Kwang-seok |
author_sort | Mirzaei, Sepideh |
collection | PubMed |
description | The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity against different cancers in both pre-clinical and clinical studies. However, drug resistance has restricted its potential in the treatment of cancer patients. CP can promote levels of free radicals, particularly reactive oxygen species (ROS) to induce cell death. Due to the double-edged sword role of ROS in cancer as a pro-survival or pro-death mechanism, ROS can result in CP resistance. In the present review, association of ROS with CP sensitivity/resistance is discussed, and in particular, how molecular pathways, both upstream and downstream targets, can affect the response of cancer cells to CP chemotherapy. Furthermore, anti-tumor compounds, such as curcumin, emodin, chloroquine that regulate ROS and related molecular pathways in increasing CP sensitivity are described. Nanoparticles can provide co-delivery of CP with anti-tumor agents and by mediating photodynamic therapy, and induce ROS overgeneration to trigger CP sensitivity. Genetic tools, such as small interfering RNA (siRNA) can down-regulate molecular pathways such as HIF-1α and Nrf2 to promote ROS levels, leading to CP sensitivity. Considering the relationship between ROS and CP chemotherapy, and translating these findings to clinic can pave the way for effective treatment of cancer patients. |
format | Online Article Text |
id | pubmed-8073650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80736502021-04-27 Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies Mirzaei, Sepideh Hushmandi, Kiavash Zabolian, Amirhossein Saleki, Hossein Torabi, Seyed Mohammad Reza Ranjbar, Adnan SeyedSaleh, SeyedHesam Sharifzadeh, Seyed Omid Khan, Haroon Ashrafizadeh, Milad Zarrabi, Ali Ahn, Kwang-seok Molecules Review The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity against different cancers in both pre-clinical and clinical studies. However, drug resistance has restricted its potential in the treatment of cancer patients. CP can promote levels of free radicals, particularly reactive oxygen species (ROS) to induce cell death. Due to the double-edged sword role of ROS in cancer as a pro-survival or pro-death mechanism, ROS can result in CP resistance. In the present review, association of ROS with CP sensitivity/resistance is discussed, and in particular, how molecular pathways, both upstream and downstream targets, can affect the response of cancer cells to CP chemotherapy. Furthermore, anti-tumor compounds, such as curcumin, emodin, chloroquine that regulate ROS and related molecular pathways in increasing CP sensitivity are described. Nanoparticles can provide co-delivery of CP with anti-tumor agents and by mediating photodynamic therapy, and induce ROS overgeneration to trigger CP sensitivity. Genetic tools, such as small interfering RNA (siRNA) can down-regulate molecular pathways such as HIF-1α and Nrf2 to promote ROS levels, leading to CP sensitivity. Considering the relationship between ROS and CP chemotherapy, and translating these findings to clinic can pave the way for effective treatment of cancer patients. MDPI 2021-04-19 /pmc/articles/PMC8073650/ /pubmed/33921908 http://dx.doi.org/10.3390/molecules26082382 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mirzaei, Sepideh Hushmandi, Kiavash Zabolian, Amirhossein Saleki, Hossein Torabi, Seyed Mohammad Reza Ranjbar, Adnan SeyedSaleh, SeyedHesam Sharifzadeh, Seyed Omid Khan, Haroon Ashrafizadeh, Milad Zarrabi, Ali Ahn, Kwang-seok Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies |
title | Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies |
title_full | Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies |
title_fullStr | Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies |
title_full_unstemmed | Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies |
title_short | Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies |
title_sort | elucidating role of reactive oxygen species (ros) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073650/ https://www.ncbi.nlm.nih.gov/pubmed/33921908 http://dx.doi.org/10.3390/molecules26082382 |
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