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Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings

Co-infections in critically ill patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have an important impact on the outcome of coronavirus disease 2019 (COVID-19). We compared the microbial isolations found in COVID-19 patients hospitalized in an intensiv...

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Autores principales: Cultrera, Rosario, Barozzi, Agostino, Libanore, Marco, Marangoni, Elisabetta, Pora, Roberto, Quarta, Brunella, Spadaro, Savino, Ragazzi, Riccardo, Marra, Anna, Segala, Daniela, Volta, Carlo Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073702/
https://www.ncbi.nlm.nih.gov/pubmed/33923992
http://dx.doi.org/10.3390/ijerph18084358
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author Cultrera, Rosario
Barozzi, Agostino
Libanore, Marco
Marangoni, Elisabetta
Pora, Roberto
Quarta, Brunella
Spadaro, Savino
Ragazzi, Riccardo
Marra, Anna
Segala, Daniela
Volta, Carlo Alberto
author_facet Cultrera, Rosario
Barozzi, Agostino
Libanore, Marco
Marangoni, Elisabetta
Pora, Roberto
Quarta, Brunella
Spadaro, Savino
Ragazzi, Riccardo
Marra, Anna
Segala, Daniela
Volta, Carlo Alberto
author_sort Cultrera, Rosario
collection PubMed
description Co-infections in critically ill patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have an important impact on the outcome of coronavirus disease 2019 (COVID-19). We compared the microbial isolations found in COVID-19 patients hospitalized in an intensive care unit (ICU) with those in a non-COVID-19 ICU from 22 February to 30 April 2020 and in the same period of 2019. We considered blood, urine or respiratory specimens obtained with bronchoalveolar lavage (BAL) or bronchial aspirate (BASP), collected from all patients admitted in ICUs with or without COVID-19 infection. We found a higher frequency of infections due to methicillin-resistant (MR) staphylococci, vancomycin-resistant Enterococcus faecium, carbapenem-resistant Acinetobacter baumannii and Candida parapsilosis in COVID-19-positive patients admitted in ICUs compared to those who were COVID-19 negative. Carbapenem-resistant Pseudomonas aeruginosa was more frequently isolated from patients admitted in non-COVID-19 ICUs. Several conditions favor the increased frequency of these infections by antibiotic-resistant microorganisms. Among all, the severity of the respiratory tracts was definitely decisive, which required assisted ventilation with invasive procedures. The turnover in the ICU of a large number of patients in a very short time requiring urgent invasive interventions has favored the not always suitable execution of assistance procedures. No less important is the increased exposure to infectious risk from bacteria and fungi in patients with severe impairment due to ventilation. The highest costs for antifungal drugs were shown in the ICU-COVID group.
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spelling pubmed-80737022021-04-27 Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings Cultrera, Rosario Barozzi, Agostino Libanore, Marco Marangoni, Elisabetta Pora, Roberto Quarta, Brunella Spadaro, Savino Ragazzi, Riccardo Marra, Anna Segala, Daniela Volta, Carlo Alberto Int J Environ Res Public Health Article Co-infections in critically ill patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have an important impact on the outcome of coronavirus disease 2019 (COVID-19). We compared the microbial isolations found in COVID-19 patients hospitalized in an intensive care unit (ICU) with those in a non-COVID-19 ICU from 22 February to 30 April 2020 and in the same period of 2019. We considered blood, urine or respiratory specimens obtained with bronchoalveolar lavage (BAL) or bronchial aspirate (BASP), collected from all patients admitted in ICUs with or without COVID-19 infection. We found a higher frequency of infections due to methicillin-resistant (MR) staphylococci, vancomycin-resistant Enterococcus faecium, carbapenem-resistant Acinetobacter baumannii and Candida parapsilosis in COVID-19-positive patients admitted in ICUs compared to those who were COVID-19 negative. Carbapenem-resistant Pseudomonas aeruginosa was more frequently isolated from patients admitted in non-COVID-19 ICUs. Several conditions favor the increased frequency of these infections by antibiotic-resistant microorganisms. Among all, the severity of the respiratory tracts was definitely decisive, which required assisted ventilation with invasive procedures. The turnover in the ICU of a large number of patients in a very short time requiring urgent invasive interventions has favored the not always suitable execution of assistance procedures. No less important is the increased exposure to infectious risk from bacteria and fungi in patients with severe impairment due to ventilation. The highest costs for antifungal drugs were shown in the ICU-COVID group. MDPI 2021-04-20 /pmc/articles/PMC8073702/ /pubmed/33923992 http://dx.doi.org/10.3390/ijerph18084358 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cultrera, Rosario
Barozzi, Agostino
Libanore, Marco
Marangoni, Elisabetta
Pora, Roberto
Quarta, Brunella
Spadaro, Savino
Ragazzi, Riccardo
Marra, Anna
Segala, Daniela
Volta, Carlo Alberto
Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings
title Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings
title_full Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings
title_fullStr Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings
title_full_unstemmed Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings
title_short Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings
title_sort co-infections in critically ill patients with or without covid-19: a comparison of clinical microbial culture findings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073702/
https://www.ncbi.nlm.nih.gov/pubmed/33923992
http://dx.doi.org/10.3390/ijerph18084358
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