Cargando…

Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines

The majority of patients with testicular germ cell tumors (GCTs) can be cured with cisplatin-based chemotherapy. However, for a subset of patients present with cisplatin-refractory disease, which confers a poor prognosis, the treatment options are limited. Novel therapies are therefore urgently need...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmidtova, Silvia, Kalavska, Katarina, Liskova, Veronika, Plava, Jana, Miklikova, Svetlana, Kucerova, Lucia, Matuskova, Miroslava, Rojikova, Lucia, Cierna, Zuzana, Rogozea, Adriana, Konig, Heiko, Albany, Costantine, Mego, Michal, Chovanec, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073733/ https://www.ncbi.nlm.nih.gov/pubmed/33923996 http://dx.doi.org/10.3390/ijms22084263

Ejemplares similares

Effect of the PARP inhibitor veliparib on germ cell tumor cell lines
por: Schmidtova, Silvia, et al.
Publicado: (2022)

Disulfiram Overcomes Cisplatin Resistance in Human Embryonal Carcinoma Cells
por: Schmidtova, Silvia, et al.
Publicado: (2019)

Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer
por: Plava, Jana, et al.
Publicado: (2019)

Immunotherapy in Testicular Germ Cell Tumors
por: Kalavska, Katarina, et al.
Publicado: (2020)

LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974
por: Jang, Jaewoong, et al.
Publicado: (2017)

ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells
por: Durinikova, Erika, et al.
Publicado: (2018)

Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors
por: Letkovska, Katarina, et al.
Publicado: (2021)

Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma
por: Li, Jianyi, et al.
Publicado: (2020)

Decreased levels of circulating cytokines VEGF, TNF-β and IL-15 indicate PD-L1 overexpression in tumours of primary breast cancer patients
por: Cierna, Zuzana, et al.
Publicado: (2021)

Emerging Prognostic Biomarkers in Testicular Germ Cell Tumors: Looking Beyond Established Practice
por: Chovanec, Michal, et al.
Publicado: (2018)

Napabucasin overcomes cisplatin resistance in ovarian germ cell tumor-derived cell line by inhibiting cancer stemness
por: Schmidtova, Silvia, et al.
Publicado: (2020)

LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways
por: Jang, Jaewoong, et al.
Publicado: (2021)

Molecular features and gene expression signature of metastatic colorectal cancer
por: Poturnajova, Martina, et al.
Publicado: (2021)

Increased Stromal Infiltrating Lymphocytes Are Associated with the Risk of Disease Progression in Mesenchymal Circulating Tumor Cell-Positive Primary Breast Cancer Patients
por: Smolkova, Bozena, et al.
Publicado: (2020)

Overcoming Chemotherapy Resistance in Germ Cell Tumors
por: Országhová, Zuzana, et al.
Publicado: (2022)

Inflammation-Based Scores Increase the Prognostic Value of Circulating Tumor Cells in Primary Breast Cancer
por: Miklikova, Svetlana, et al.
Publicado: (2020)

Chemotherapy-triggered changes in stromal compartment drive tumor invasiveness and progression of breast cancer
por: Plava, Jana, et al.
Publicado: (2021)

Combined enzyme/prodrug treatment by genetically engineered AT-MSC exerts synergy and inhibits growth of MDA-MB-231 induced lung metastases
por: Matuskova, Miroslava, et al.
Publicado: (2015)

Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy
por: Plava, Jana, et al.
Publicado: (2020)

Prognostic role of programmed-death ligand 1 (PD-L1) expressing tumor infiltrating lymphocytes in testicular germ cell tumors
por: Chovanec, Michal, et al.
Publicado: (2017)

Porcupine inhibitor LGK-974 inhibits Wnt/β-catenin signaling and modifies tumor-associated macrophages resulting in inhibition of the malignant behaviors of non-small cell lung cancer cells
por: Tang, Yang, et al.
Publicado: (2021)

βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors
por: Chovanec, Michal, et al.
Publicado: (2018)

Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
por: Cierna, Zuzana, et al.
Publicado: (2020)

Glycan signatures for the identification of cisplatin‐resistant testicular cancer cell lines: Specific glycoprofiling of human chorionic gonadotropin (hCG)
por: Hires, Michal, et al.
Publicado: (2022)

Systemic immune-inflammation index in germ-cell tumours
por: Chovanec, Michal, et al.
Publicado: (2018)

Tyrosine kinase inhibitor SU11274 increased tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation
por: Kucerova, Lucia, et al.
Publicado: (2016)

Tumor cell behaviour modulation by mesenchymal stromal cells
por: Kucerova, Lucia, et al.
Publicado: (2010)

Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells
por: Kucerova, Lucia, et al.
Publicado: (2013)

Fibrillin-1 (FBN-1) a new marker of germ cell neoplasia in situ
por: Cierna, Z., et al.
Publicado: (2016)

Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors
por: Kalavska, Katarina, et al.
Publicado: (2017)

Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells
por: Skolekova, Svetlana, et al.
Publicado: (2016)

Exploring the Potential Role of the Gut Microbiome in Chemotherapy-Induced Neurocognitive Disorders and Cardiovascular Toxicity
por: Ciernikova, Sona, et al.
Publicado: (2021)

Long-Term Cognitive Dysfunction in Cancer Survivors
por: Országhová, Zuzana, et al.
Publicado: (2021)

Prognostic role of matrix metalloproteinase 9 in early breast cancer
por: Kalavska, Katarina, et al.
Publicado: (2021)

Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells
por: Kleszcz, Robert, et al.
Publicado: (2023)

Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors
por: Chovanec, Michal, et al.
Publicado: (2018)

Anti-myelin-associated glycoprotein peripheral neuropathy as the only presentation of low grade lymphoma: a case report
por: Albany, Costantine
Publicado: (2009)

Systemic immune-inflammation index in germ-cell tumours: search for a biological prognostic biomarker
por: Albany, Costantine
Publicado: (2018)

Comprehensive Assessment of Selected Immune Cell Subpopulations Changes in Chemotherapy-Naïve Germ Cell Tumor Patients
por: Kalavska, Katarina, et al.
Publicado: (2022)

Detection of Specific Immune Cell Subpopulation Changes Associated with Systemic Immune Inflammation–Index Level in Germ Cell Tumors
por: Kalavska, Katarina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2ijh70j0rdtsqvlijnejjal61n