Adenovirus-Mediated Inducible Expression of a PD-L1 Blocking Antibody in Combination with Macrophage Depletion Improves Survival in a Mouse Model of Peritoneal Carcinomatosis

Immune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in a growing number of malignancies. However, overcoming primary or secondary resistances is difficult due to pharmacokinetics issues and side effects associated with high systemic exposure. Local or regional expression of mon...

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Detalles Bibliográficos
Autores principales: Buñuales, Maria, Ballesteros-Briones, Maria Cristina, Gonzalez-Aparicio, Manuela, Hervas-Stubbs, Sandra, Martisova, Eva, Mancheño, Uxua, Ricobaraza, Ana, Lumbreras, Sara, Smerdou, Cristian, Hernandez-Alcoceba, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073765/
https://www.ncbi.nlm.nih.gov/pubmed/33920699
http://dx.doi.org/10.3390/ijms22084176

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