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A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis

(1) Background: The emergence of injectable “biologic” medication creates a new approach to treat osteoarthritis (OA). Among them, the use of intra-articular injection of PRP became widespread despite the absence of consensus regarding its optimal composition. The aim of this study was to retrospect...

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Autores principales: Bec, Cécilia, Rousset, Axelle, Brandin, Thibault, François, Pauline, Rabarimeriarijaona, Sitraka, Dumoulin, Chloé, Heleu, Gaëlle, Grimaud, Fanny, Veran, Julie, Magalon, Guy, Dignat-George, Françoise, Sabatier, Florence, Louis, Marie-Laure, Magalon, Jérémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073986/
https://www.ncbi.nlm.nih.gov/pubmed/33920633
http://dx.doi.org/10.3390/jcm10081748
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author Bec, Cécilia
Rousset, Axelle
Brandin, Thibault
François, Pauline
Rabarimeriarijaona, Sitraka
Dumoulin, Chloé
Heleu, Gaëlle
Grimaud, Fanny
Veran, Julie
Magalon, Guy
Dignat-George, Françoise
Sabatier, Florence
Louis, Marie-Laure
Magalon, Jérémy
author_facet Bec, Cécilia
Rousset, Axelle
Brandin, Thibault
François, Pauline
Rabarimeriarijaona, Sitraka
Dumoulin, Chloé
Heleu, Gaëlle
Grimaud, Fanny
Veran, Julie
Magalon, Guy
Dignat-George, Françoise
Sabatier, Florence
Louis, Marie-Laure
Magalon, Jérémy
author_sort Bec, Cécilia
collection PubMed
description (1) Background: The emergence of injectable “biologic” medication creates a new approach to treat osteoarthritis (OA). Among them, the use of intra-articular injection of PRP became widespread despite the absence of consensus regarding its optimal composition. The aim of this study was to retrospectively correlate an extensive biological characterization of injected PRP to the clinical responses of patients presenting knee OA. (2) Methods: This retrospective study included 75 patients with knee OA. Cartilage lesions were assessed using magnetic resonance imaging and the International Cartilage Regeneration Society (ICRS) classification. PRP extensive biological characterization was performed and patients’ subjective symptoms were recorded before injection and 3 and 6 months after injection using the Knee injury and Osteoarthritis Outcome Score (KOOS). Responders were defined by an improvement of 10 points on KOOS. (3) Results: At 6 months, 63.0% of the patients were responders. Impairment was characterized by a significantly higher proportion of patients with three compartments altered at baseline MRI and receiving a significantly higher dose of platelets compared to responders. (4) Conclusions: Single injection of pure PRP resulted in significant clinical improvement in the management of knee OA. Both baseline MRI and PRP biological features may be predictive factors of the clinical response, highlighting that a better understanding of action mechanism of PRP is still required.
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spelling pubmed-80739862021-04-27 A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis Bec, Cécilia Rousset, Axelle Brandin, Thibault François, Pauline Rabarimeriarijaona, Sitraka Dumoulin, Chloé Heleu, Gaëlle Grimaud, Fanny Veran, Julie Magalon, Guy Dignat-George, Françoise Sabatier, Florence Louis, Marie-Laure Magalon, Jérémy J Clin Med Article (1) Background: The emergence of injectable “biologic” medication creates a new approach to treat osteoarthritis (OA). Among them, the use of intra-articular injection of PRP became widespread despite the absence of consensus regarding its optimal composition. The aim of this study was to retrospectively correlate an extensive biological characterization of injected PRP to the clinical responses of patients presenting knee OA. (2) Methods: This retrospective study included 75 patients with knee OA. Cartilage lesions were assessed using magnetic resonance imaging and the International Cartilage Regeneration Society (ICRS) classification. PRP extensive biological characterization was performed and patients’ subjective symptoms were recorded before injection and 3 and 6 months after injection using the Knee injury and Osteoarthritis Outcome Score (KOOS). Responders were defined by an improvement of 10 points on KOOS. (3) Results: At 6 months, 63.0% of the patients were responders. Impairment was characterized by a significantly higher proportion of patients with three compartments altered at baseline MRI and receiving a significantly higher dose of platelets compared to responders. (4) Conclusions: Single injection of pure PRP resulted in significant clinical improvement in the management of knee OA. Both baseline MRI and PRP biological features may be predictive factors of the clinical response, highlighting that a better understanding of action mechanism of PRP is still required. MDPI 2021-04-17 /pmc/articles/PMC8073986/ /pubmed/33920633 http://dx.doi.org/10.3390/jcm10081748 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bec, Cécilia
Rousset, Axelle
Brandin, Thibault
François, Pauline
Rabarimeriarijaona, Sitraka
Dumoulin, Chloé
Heleu, Gaëlle
Grimaud, Fanny
Veran, Julie
Magalon, Guy
Dignat-George, Françoise
Sabatier, Florence
Louis, Marie-Laure
Magalon, Jérémy
A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis
title A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis
title_full A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis
title_fullStr A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis
title_full_unstemmed A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis
title_short A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis
title_sort retrospective analysis of characteristic features of responders and impaired patients to a single injection of pure platelet-rich plasma in knee osteoarthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073986/
https://www.ncbi.nlm.nih.gov/pubmed/33920633
http://dx.doi.org/10.3390/jcm10081748
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