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Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together
Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074054/ https://www.ncbi.nlm.nih.gov/pubmed/33923948 http://dx.doi.org/10.3390/nu13041378 |
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author | Palmese, Francesco Del Toro, Rossella Di Marzio, Giulia Cataleta, Pierluigi Sama, Maria Giulia Domenicali, Marco |
author_facet | Palmese, Francesco Del Toro, Rossella Di Marzio, Giulia Cataleta, Pierluigi Sama, Maria Giulia Domenicali, Marco |
author_sort | Palmese, Francesco |
collection | PubMed |
description | Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step of the clinical management of these patients. Patients with CD are frequently malnourished, presenting a high prevalence of different macro- and micro-nutrient deficiencies, including that of vitamin D. The available published studies indicate that vitamin D is involved in the regulation of proliferation, differentiation, and regeneration of muscle cells. The relationship between vitamin D deficiency and sarcopenia has been extensively studied in other populations, with interesting evidence in regards to a potential role of vitamin D supplementation as a means to prevent and treat sarcopenia. The aim of this review was to find studies that linked together these pathological conditions. |
format | Online Article Text |
id | pubmed-8074054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80740542021-04-27 Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together Palmese, Francesco Del Toro, Rossella Di Marzio, Giulia Cataleta, Pierluigi Sama, Maria Giulia Domenicali, Marco Nutrients Review Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step of the clinical management of these patients. Patients with CD are frequently malnourished, presenting a high prevalence of different macro- and micro-nutrient deficiencies, including that of vitamin D. The available published studies indicate that vitamin D is involved in the regulation of proliferation, differentiation, and regeneration of muscle cells. The relationship between vitamin D deficiency and sarcopenia has been extensively studied in other populations, with interesting evidence in regards to a potential role of vitamin D supplementation as a means to prevent and treat sarcopenia. The aim of this review was to find studies that linked together these pathological conditions. MDPI 2021-04-20 /pmc/articles/PMC8074054/ /pubmed/33923948 http://dx.doi.org/10.3390/nu13041378 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Palmese, Francesco Del Toro, Rossella Di Marzio, Giulia Cataleta, Pierluigi Sama, Maria Giulia Domenicali, Marco Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together |
title | Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together |
title_full | Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together |
title_fullStr | Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together |
title_full_unstemmed | Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together |
title_short | Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together |
title_sort | sarcopenia and vitamin d deficiency in patients with crohn’s disease: pathological conditions that should be linked together |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074054/ https://www.ncbi.nlm.nih.gov/pubmed/33923948 http://dx.doi.org/10.3390/nu13041378 |
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