Cargando…

A Computational Model for Pain Processing in the Dorsal Horn Following Axonal Damage to Receptor Fibers

Computational modeling of the neural activity in the human spinal cord may help elucidate the underlying mechanisms involved in the complex processing of painful stimuli. In this study, we use a biologically-plausible model of the dorsal horn circuitry as a platform to simulate pain processing under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crodelle, Jennifer, Maia, Pedro D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074099/ https://www.ncbi.nlm.nih.gov/pubmed/33923490 http://dx.doi.org/10.3390/brainsci11040505

Ejemplares similares

Modeling the daily rhythm of human pain processing in the dorsal horn
por: Crodelle, Jennifer, et al.
Publicado: (2019)

Projection Neuron Axon Collaterals in the Dorsal Horn: Placing a New Player in Spinal Cord Pain Processing
por: Browne, Tyler J., et al.
Publicado: (2020)

Central Connectivity of Transient Receptor Potential Melastatin 8-Expressing Axons in the Brain Stem and Spinal Dorsal Horn
por: Kim, Yun Sook, et al.
Publicado: (2014)

Quantitative Study of NPY-Expressing GABAergic Neurons and Axons in Rat Spinal Dorsal Horn*
por: Polgár, Erika, et al.
Publicado: (2011)

Neuritis and vinblastine-induced axonal transport disruption lead to signs of altered dorsal horn excitability
por: Satkeviciute, Ieva, et al.
Publicado: (2018)

Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations
por: Fan, Wei, et al.
Publicado: (2022)

Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain
por: Shi, Tie-Jun Sten, et al.
Publicado: (2014)

Defining populations of dorsal horn interneurons
por: Graham, Brett A., et al.
Publicado: (2020)

Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn
por: Nelson, Tyler S., et al.
Publicado: (2019)

Ca(2+)-Permeable AMPA Receptors Contribute to Changed Dorsal Horn Neuronal Firing and Inflammatory Pain
por: Kopach, Olga, et al.
Publicado: (2023)

Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain
por: Wu, Yuning, et al.
Publicado: (2023)

Limited changes in spinal lamina I dorsal horn neurons following the cytotoxic ablation of non-peptidergic C-fibers
por: Saeed, Abeer W., et al.
Publicado: (2015)

Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons
por: Nishida, Kazuhiko, et al.
Publicado: (2023)

Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model
por: Zhang, Enji, et al.
Publicado: (2015)

Expression of granulocyte colony-stimulating factor 3 receptor in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain
por: Zhang, Enji, et al.
Publicado: (2017)

Pain-related synaptic plasticity in spinal dorsal horn neurons: role of CGRP
por: Bird, Gary C, et al.
Publicado: (2006)

Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn
por: Ohashi, Nobuko, et al.
Publicado: (2015)

Proteomic Analysis of the Spinal Dorsal Horn in Mice with Neuropathic Pain After Exercise
por: Bai, Jie, et al.
Publicado: (2023)

Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain
por: Zhang, Zhi-Jun, et al.
Publicado: (2012)

Key role for spinal dorsal horn microglial kinin B(1 )receptor in early diabetic pain neuropathy
por: Talbot, Sébastien, et al.
Publicado: (2010)

Mechanism of dorsal root ganglion stimulation for pain relief in painful diabetic polyneuropathy is not dependent on GABA release in the dorsal horn of the spinal cord
por: Koetsier, Eva, et al.
Publicado: (2019)

Methylcobalamin ameliorates neuropathic pain induced by vincristine in rats: Effect on loss of peripheral nerve fibers and imbalance of cytokines in the spinal dorsal horn
por: Xu, Jing, et al.
Publicado: (2016)

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn
por: Abraira, Victoria E., et al.
Publicado: (2017)

Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
por: Imlach, Wendy L., et al.
Publicado: (2016)

Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors
por: Zhang, Yu, et al.
Publicado: (2023)

Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model
por: Fujita, Masahide, et al.
Publicado: (2018)

The effect of µ-opioid receptor activation on GABAergic neurons in the spinal dorsal horn
por: Kim, Yoo Rim, et al.
Publicado: (2018)

Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord
por: Leonardon, Benjamin, et al.
Publicado: (2022)

Translation regulation in the spinal dorsal horn – A key mechanism for development of chronic pain
por: Tansley, Shannon N., et al.
Publicado: (2018)

Neurexin‐2 is a potential regulator of inflammatory pain in the spinal dorsal horn of rats
por: Xu, Longsheng, et al.
Publicado: (2020)

Proteomics Analysis of the Spinal Dorsal Horn in Diabetic Painful Neuropathy Rats With Electroacupuncture Treatment
por: Yu, Xiangmei, et al.
Publicado: (2021)

Modeling homeostatic and circadian modulation of human pain sensitivity
por: Crodelle, Jennifer, et al.
Publicado: (2023)

Pentraxin-3 in the Spinal Dorsal Horn Upregulates Nectin-1 Expression in Neuropathic Pain after Spinal Nerve Damage in Male Mice
por: Zhu, Min, et al.
Publicado: (2022)

Neuronal P2X4 receptor may contribute to peripheral inflammatory pain in rat spinal dorsal horn
por: Ducza, László, et al.
Publicado: (2023)

THE RESPONSE OF VENTRAL HORN NEURONS TO AXONAL TRANSECTION
por: Price, Donald L., et al.
Publicado: (1972)

Impacts of anti-nerve growth factor antibody on pain-related behaviors and expressions of opioid receptor in spinal dorsal horn and dorsal root ganglia of rats with cancer-induced bone pain
por: Yao, Peng, et al.
Publicado: (2016)

Histone deacetylase 2 is involved in µ-opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain
por: Liao, Yong-Hui, et al.
Publicado: (2018)

Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn
por: Chamessian, Alexander, et al.
Publicado: (2018)

Expression of cholecystokinin by neurons in mouse spinal dorsal horn
por: Gutierrez‐Mecinas, Maria, et al.
Publicado: (2019)

Analgesic effect of gastrin-releasing peptide in the dorsal horn
por: Saeki, Ayano, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fco2f0ib5239cnboo1r7r5aqf1