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COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan

Background: Data have not been reported to explore the relation between COVID-19 severity and BCG vaccination status at the individual patient level. Methods: Taiwan has a nationwide neonatal BCG vaccination program that was launched in 1965. The Taiwan Centers for Disease Control established a web-...

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Autores principales: Su, Wei-Ju, Chang, Chia-Hsuin, Wang, Jiun-Ling, Chen, Shu-Fong, Yang, Chin-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074147/
https://www.ncbi.nlm.nih.gov/pubmed/33919644
http://dx.doi.org/10.3390/ijerph18084303
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author Su, Wei-Ju
Chang, Chia-Hsuin
Wang, Jiun-Ling
Chen, Shu-Fong
Yang, Chin-Hui
author_facet Su, Wei-Ju
Chang, Chia-Hsuin
Wang, Jiun-Ling
Chen, Shu-Fong
Yang, Chin-Hui
author_sort Su, Wei-Ju
collection PubMed
description Background: Data have not been reported to explore the relation between COVID-19 severity and BCG vaccination status at the individual patient level. Methods: Taiwan has a nationwide neonatal BCG vaccination program that was launched in 1965. The Taiwan Centers for Disease Control established a web-based National Immunization Information System (NISS) in 2003 and included all citizens’ BCG vaccination records in NISS for those born after 1985. We identified COVID-19 Taiwanese patients born after 1985 between 21 January and 19 March 2021. Study participants were further classified into ages 4–24 years (birth year 1996–2016) and 25–33 years (birth year 1986–1995). We described their clinical syndrome defined by the World Health Organization and examined the relation between the COVID-19 severity and BCG vaccination status. Results: In the 4–24 age group, among 138 BCG vaccinated individuals, 80.4% were asymptomatic or had mild disease, while 17.4% had moderate disease, 1.5% had severe disease, and 0.7% had acute respiratory distress syndrome but none of them died. In contrast, all 6 BCG unvaccinated individuals in this age group experienced mild illness. In the 25–33 age group, moderate disease occurred in 14.2% and severe disease occurred in 0.9% of the 106 patients without neonatal BCG vaccination records, as compared to 19.2% had moderate disease and none had severe or critical disease of the 78 patients with neonatal BCG vaccination records. Conclusions: Our finding indicated that BCG immunization might not relate to COVID-19 severity in the young population.
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spelling pubmed-80741472021-04-27 COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan Su, Wei-Ju Chang, Chia-Hsuin Wang, Jiun-Ling Chen, Shu-Fong Yang, Chin-Hui Int J Environ Res Public Health Communication Background: Data have not been reported to explore the relation between COVID-19 severity and BCG vaccination status at the individual patient level. Methods: Taiwan has a nationwide neonatal BCG vaccination program that was launched in 1965. The Taiwan Centers for Disease Control established a web-based National Immunization Information System (NISS) in 2003 and included all citizens’ BCG vaccination records in NISS for those born after 1985. We identified COVID-19 Taiwanese patients born after 1985 between 21 January and 19 March 2021. Study participants were further classified into ages 4–24 years (birth year 1996–2016) and 25–33 years (birth year 1986–1995). We described their clinical syndrome defined by the World Health Organization and examined the relation between the COVID-19 severity and BCG vaccination status. Results: In the 4–24 age group, among 138 BCG vaccinated individuals, 80.4% were asymptomatic or had mild disease, while 17.4% had moderate disease, 1.5% had severe disease, and 0.7% had acute respiratory distress syndrome but none of them died. In contrast, all 6 BCG unvaccinated individuals in this age group experienced mild illness. In the 25–33 age group, moderate disease occurred in 14.2% and severe disease occurred in 0.9% of the 106 patients without neonatal BCG vaccination records, as compared to 19.2% had moderate disease and none had severe or critical disease of the 78 patients with neonatal BCG vaccination records. Conclusions: Our finding indicated that BCG immunization might not relate to COVID-19 severity in the young population. MDPI 2021-04-18 /pmc/articles/PMC8074147/ /pubmed/33919644 http://dx.doi.org/10.3390/ijerph18084303 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Su, Wei-Ju
Chang, Chia-Hsuin
Wang, Jiun-Ling
Chen, Shu-Fong
Yang, Chin-Hui
COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan
title COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan
title_full COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan
title_fullStr COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan
title_full_unstemmed COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan
title_short COVID-19 Severity and Neonatal BCG Vaccination among Young Population in Taiwan
title_sort covid-19 severity and neonatal bcg vaccination among young population in taiwan
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074147/
https://www.ncbi.nlm.nih.gov/pubmed/33919644
http://dx.doi.org/10.3390/ijerph18084303
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