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FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study

Background: FDG-PET/CT is a noninvasive examination that could be helpful for the management of endometrial cancer. The aim of this study was to evaluate the performance of FDG-PET/CT in assessing para-aortic lymph-node involvement in high-risk endometrial cancer. Methods: We performed a retrospecti...

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Autores principales: Sallée, Camille, Margueritte, François, Gouy, Sébastien, Tardieu, Antoine, Belghiti, Jérémie, Lambaudie, Eric, Collinet, Pierre, Guyon, Frédéric, Legros, Maxime, Monteil, Jacques, Gauthier, Tristan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074207/
https://www.ncbi.nlm.nih.gov/pubmed/33920565
http://dx.doi.org/10.3390/jcm10081746
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author Sallée, Camille
Margueritte, François
Gouy, Sébastien
Tardieu, Antoine
Belghiti, Jérémie
Lambaudie, Eric
Collinet, Pierre
Guyon, Frédéric
Legros, Maxime
Monteil, Jacques
Gauthier, Tristan
author_facet Sallée, Camille
Margueritte, François
Gouy, Sébastien
Tardieu, Antoine
Belghiti, Jérémie
Lambaudie, Eric
Collinet, Pierre
Guyon, Frédéric
Legros, Maxime
Monteil, Jacques
Gauthier, Tristan
author_sort Sallée, Camille
collection PubMed
description Background: FDG-PET/CT is a noninvasive examination that could be helpful for the management of endometrial cancer. The aim of this study was to evaluate the performance of FDG-PET/CT in assessing para-aortic lymph-node involvement in high-risk endometrial cancer. Methods: We performed a retrospective multicenter study including all patients who had a high-risk endometrial cancer with a preoperative FDG-PET/CT and a para-aortic lymphadenectomy (PAL) between 2009 and 2019. The main objective was to evaluate the overall performance of FDG-PET/CT. The secondary objectives were to evaluate its performances according to the histological type and according to FDG-PET/CT date (before or after hysterectomy), and to compare its overall performance with that of the MRI scan. Results: We included 200 patients from six different centers. After the false positive FDG-PET/CT was reread by nuclear physicians, FDG-PET/CT had a sensitivity of 61.8%, a specificity of 89.7%, a positive predictive value of 69.4%, a negative predictive value of 86.1%, and an AUC of 0.76. There were no statistically significant differences in the performances according to either histological type and or FDG-PET/CT date. The sensitivity of FDG-PET/CT was better than that of MRI (p < 0.01), but the specificity was not (p = 0.82). Conclusion: Currently, FDG-PET/CT alone cannot replace PAL for the lymph node evaluation of high-risk endometrial cancers. It seems essential to reread it in multidisciplinary meetings before validating the therapeutic management of patients, particularly in the case of isolated para-aortic involvement.
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spelling pubmed-80742072021-04-27 FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study Sallée, Camille Margueritte, François Gouy, Sébastien Tardieu, Antoine Belghiti, Jérémie Lambaudie, Eric Collinet, Pierre Guyon, Frédéric Legros, Maxime Monteil, Jacques Gauthier, Tristan J Clin Med Article Background: FDG-PET/CT is a noninvasive examination that could be helpful for the management of endometrial cancer. The aim of this study was to evaluate the performance of FDG-PET/CT in assessing para-aortic lymph-node involvement in high-risk endometrial cancer. Methods: We performed a retrospective multicenter study including all patients who had a high-risk endometrial cancer with a preoperative FDG-PET/CT and a para-aortic lymphadenectomy (PAL) between 2009 and 2019. The main objective was to evaluate the overall performance of FDG-PET/CT. The secondary objectives were to evaluate its performances according to the histological type and according to FDG-PET/CT date (before or after hysterectomy), and to compare its overall performance with that of the MRI scan. Results: We included 200 patients from six different centers. After the false positive FDG-PET/CT was reread by nuclear physicians, FDG-PET/CT had a sensitivity of 61.8%, a specificity of 89.7%, a positive predictive value of 69.4%, a negative predictive value of 86.1%, and an AUC of 0.76. There were no statistically significant differences in the performances according to either histological type and or FDG-PET/CT date. The sensitivity of FDG-PET/CT was better than that of MRI (p < 0.01), but the specificity was not (p = 0.82). Conclusion: Currently, FDG-PET/CT alone cannot replace PAL for the lymph node evaluation of high-risk endometrial cancers. It seems essential to reread it in multidisciplinary meetings before validating the therapeutic management of patients, particularly in the case of isolated para-aortic involvement. MDPI 2021-04-17 /pmc/articles/PMC8074207/ /pubmed/33920565 http://dx.doi.org/10.3390/jcm10081746 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sallée, Camille
Margueritte, François
Gouy, Sébastien
Tardieu, Antoine
Belghiti, Jérémie
Lambaudie, Eric
Collinet, Pierre
Guyon, Frédéric
Legros, Maxime
Monteil, Jacques
Gauthier, Tristan
FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study
title FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study
title_full FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study
title_fullStr FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study
title_full_unstemmed FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study
title_short FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study
title_sort fdg-pet/ct and para-aortic staging in endometrial cancer. a french multicentric study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074207/
https://www.ncbi.nlm.nih.gov/pubmed/33920565
http://dx.doi.org/10.3390/jcm10081746
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