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FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study
Background: FDG-PET/CT is a noninvasive examination that could be helpful for the management of endometrial cancer. The aim of this study was to evaluate the performance of FDG-PET/CT in assessing para-aortic lymph-node involvement in high-risk endometrial cancer. Methods: We performed a retrospecti...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074207/ https://www.ncbi.nlm.nih.gov/pubmed/33920565 http://dx.doi.org/10.3390/jcm10081746 |
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author | Sallée, Camille Margueritte, François Gouy, Sébastien Tardieu, Antoine Belghiti, Jérémie Lambaudie, Eric Collinet, Pierre Guyon, Frédéric Legros, Maxime Monteil, Jacques Gauthier, Tristan |
author_facet | Sallée, Camille Margueritte, François Gouy, Sébastien Tardieu, Antoine Belghiti, Jérémie Lambaudie, Eric Collinet, Pierre Guyon, Frédéric Legros, Maxime Monteil, Jacques Gauthier, Tristan |
author_sort | Sallée, Camille |
collection | PubMed |
description | Background: FDG-PET/CT is a noninvasive examination that could be helpful for the management of endometrial cancer. The aim of this study was to evaluate the performance of FDG-PET/CT in assessing para-aortic lymph-node involvement in high-risk endometrial cancer. Methods: We performed a retrospective multicenter study including all patients who had a high-risk endometrial cancer with a preoperative FDG-PET/CT and a para-aortic lymphadenectomy (PAL) between 2009 and 2019. The main objective was to evaluate the overall performance of FDG-PET/CT. The secondary objectives were to evaluate its performances according to the histological type and according to FDG-PET/CT date (before or after hysterectomy), and to compare its overall performance with that of the MRI scan. Results: We included 200 patients from six different centers. After the false positive FDG-PET/CT was reread by nuclear physicians, FDG-PET/CT had a sensitivity of 61.8%, a specificity of 89.7%, a positive predictive value of 69.4%, a negative predictive value of 86.1%, and an AUC of 0.76. There were no statistically significant differences in the performances according to either histological type and or FDG-PET/CT date. The sensitivity of FDG-PET/CT was better than that of MRI (p < 0.01), but the specificity was not (p = 0.82). Conclusion: Currently, FDG-PET/CT alone cannot replace PAL for the lymph node evaluation of high-risk endometrial cancers. It seems essential to reread it in multidisciplinary meetings before validating the therapeutic management of patients, particularly in the case of isolated para-aortic involvement. |
format | Online Article Text |
id | pubmed-8074207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80742072021-04-27 FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study Sallée, Camille Margueritte, François Gouy, Sébastien Tardieu, Antoine Belghiti, Jérémie Lambaudie, Eric Collinet, Pierre Guyon, Frédéric Legros, Maxime Monteil, Jacques Gauthier, Tristan J Clin Med Article Background: FDG-PET/CT is a noninvasive examination that could be helpful for the management of endometrial cancer. The aim of this study was to evaluate the performance of FDG-PET/CT in assessing para-aortic lymph-node involvement in high-risk endometrial cancer. Methods: We performed a retrospective multicenter study including all patients who had a high-risk endometrial cancer with a preoperative FDG-PET/CT and a para-aortic lymphadenectomy (PAL) between 2009 and 2019. The main objective was to evaluate the overall performance of FDG-PET/CT. The secondary objectives were to evaluate its performances according to the histological type and according to FDG-PET/CT date (before or after hysterectomy), and to compare its overall performance with that of the MRI scan. Results: We included 200 patients from six different centers. After the false positive FDG-PET/CT was reread by nuclear physicians, FDG-PET/CT had a sensitivity of 61.8%, a specificity of 89.7%, a positive predictive value of 69.4%, a negative predictive value of 86.1%, and an AUC of 0.76. There were no statistically significant differences in the performances according to either histological type and or FDG-PET/CT date. The sensitivity of FDG-PET/CT was better than that of MRI (p < 0.01), but the specificity was not (p = 0.82). Conclusion: Currently, FDG-PET/CT alone cannot replace PAL for the lymph node evaluation of high-risk endometrial cancers. It seems essential to reread it in multidisciplinary meetings before validating the therapeutic management of patients, particularly in the case of isolated para-aortic involvement. MDPI 2021-04-17 /pmc/articles/PMC8074207/ /pubmed/33920565 http://dx.doi.org/10.3390/jcm10081746 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sallée, Camille Margueritte, François Gouy, Sébastien Tardieu, Antoine Belghiti, Jérémie Lambaudie, Eric Collinet, Pierre Guyon, Frédéric Legros, Maxime Monteil, Jacques Gauthier, Tristan FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study |
title | FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study |
title_full | FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study |
title_fullStr | FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study |
title_full_unstemmed | FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study |
title_short | FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study |
title_sort | fdg-pet/ct and para-aortic staging in endometrial cancer. a french multicentric study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074207/ https://www.ncbi.nlm.nih.gov/pubmed/33920565 http://dx.doi.org/10.3390/jcm10081746 |
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