Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers

The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, materna...

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Autores principales: Wołodko, Karolina, Castillo-Fernandez, Juan, Kelsey, Gavin, Galvão, António
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074257/
https://www.ncbi.nlm.nih.gov/pubmed/33924072
http://dx.doi.org/10.3390/ijms22084270
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author Wołodko, Karolina
Castillo-Fernandez, Juan
Kelsey, Gavin
Galvão, António
author_facet Wołodko, Karolina
Castillo-Fernandez, Juan
Kelsey, Gavin
Galvão, António
author_sort Wołodko, Karolina
collection PubMed
description The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.
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spelling pubmed-80742572021-04-27 Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers Wołodko, Karolina Castillo-Fernandez, Juan Kelsey, Gavin Galvão, António Int J Mol Sci Review The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women. MDPI 2021-04-20 /pmc/articles/PMC8074257/ /pubmed/33924072 http://dx.doi.org/10.3390/ijms22084270 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wołodko, Karolina
Castillo-Fernandez, Juan
Kelsey, Gavin
Galvão, António
Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
title Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
title_full Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
title_fullStr Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
title_full_unstemmed Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
title_short Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
title_sort revisiting the impact of local leptin signaling in folliculogenesis and oocyte maturation in obese mothers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074257/
https://www.ncbi.nlm.nih.gov/pubmed/33924072
http://dx.doi.org/10.3390/ijms22084270
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AT kelseygavin revisitingtheimpactoflocalleptinsignalinginfolliculogenesisandoocytematurationinobesemothers
AT galvaoantonio revisitingtheimpactoflocalleptinsignalinginfolliculogenesisandoocytematurationinobesemothers

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