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Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery
Over the past decade, indications for transcatheter aortic valve implantation (TAVI) have progressed rapidly—procedural numbers now exceed those of surgical aortic valve replacement (SAVR) in many countries, and TAVI is now a realistic and attractive alternative to SAVR in low-risk patients. Neuroco...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074293/ https://www.ncbi.nlm.nih.gov/pubmed/33924077 http://dx.doi.org/10.3390/jcm10081789 |
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author | Aroney, Nicholas Patterson, Tiffany Allen, Christopher Redwood, Simon Prendergast, Bernard |
author_facet | Aroney, Nicholas Patterson, Tiffany Allen, Christopher Redwood, Simon Prendergast, Bernard |
author_sort | Aroney, Nicholas |
collection | PubMed |
description | Over the past decade, indications for transcatheter aortic valve implantation (TAVI) have progressed rapidly—procedural numbers now exceed those of surgical aortic valve replacement (SAVR) in many countries, and TAVI is now a realistic and attractive alternative to SAVR in low-risk patients. Neurocognitive outcomes after TAVI and SAVR remain an issue and sit firmly under the spotlight as TAVI moves into low-risk cohorts. Cognitive decline and stroke carry a significant burden and predict future functional decline, reduced mobility, poor quality of life and increased mortality. Early TAVI trials used varying neurocognitive definitions, and outcomes differed significantly as a result. Recent international consensus statements defining endpoints following TAVI and SAVR have standardised neurological outcomes and facilitate interpretation and comparison between trials. The latest TAVI and SAVR trials have demonstrated more consistent and favourable neurocognitive outcomes for TAVI patients, and cerebral embolic protection devices offer the prospect of further refinement and improvement. |
format | Online Article Text |
id | pubmed-8074293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80742932021-04-27 Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery Aroney, Nicholas Patterson, Tiffany Allen, Christopher Redwood, Simon Prendergast, Bernard J Clin Med Review Over the past decade, indications for transcatheter aortic valve implantation (TAVI) have progressed rapidly—procedural numbers now exceed those of surgical aortic valve replacement (SAVR) in many countries, and TAVI is now a realistic and attractive alternative to SAVR in low-risk patients. Neurocognitive outcomes after TAVI and SAVR remain an issue and sit firmly under the spotlight as TAVI moves into low-risk cohorts. Cognitive decline and stroke carry a significant burden and predict future functional decline, reduced mobility, poor quality of life and increased mortality. Early TAVI trials used varying neurocognitive definitions, and outcomes differed significantly as a result. Recent international consensus statements defining endpoints following TAVI and SAVR have standardised neurological outcomes and facilitate interpretation and comparison between trials. The latest TAVI and SAVR trials have demonstrated more consistent and favourable neurocognitive outcomes for TAVI patients, and cerebral embolic protection devices offer the prospect of further refinement and improvement. MDPI 2021-04-20 /pmc/articles/PMC8074293/ /pubmed/33924077 http://dx.doi.org/10.3390/jcm10081789 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aroney, Nicholas Patterson, Tiffany Allen, Christopher Redwood, Simon Prendergast, Bernard Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery |
title | Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery |
title_full | Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery |
title_fullStr | Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery |
title_full_unstemmed | Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery |
title_short | Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery |
title_sort | neurocognitive status after aortic valve replacement: differences between tavi and surgery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074293/ https://www.ncbi.nlm.nih.gov/pubmed/33924077 http://dx.doi.org/10.3390/jcm10081789 |
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