Organoid: a powerful tool to study lung regeneration and disease

Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, regeneration and disease, and provide an in vitro model for drug screening. This review sum...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Tiantian, Cao, Yiyuan, Zhao, Peng, Shen, Shengxi, Xi, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074347/
https://www.ncbi.nlm.nih.gov/pubmed/33900491
http://dx.doi.org/10.1186/s13619-021-00082-8
_version_ 1783684334364917760
author Lu, Tiantian
Cao, Yiyuan
Zhao, Peng
Shen, Shengxi
Xi, Ying
author_facet Lu, Tiantian
Cao, Yiyuan
Zhao, Peng
Shen, Shengxi
Xi, Ying
author_sort Lu, Tiantian
collection PubMed
description Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, regeneration and disease, and provide an in vitro model for drug screening. This review summarizes the recent advances of organoid cultures derived from adult lung stem cells and human pluripotent stem cells, especially focusing on the organoids of the distal airway stem/progenitor cells. We also discuss the applications of organoids in studying lung regeneration and pulmonary diseases, including pulmonary fibrosis, airway diseases and Coronavirus disease 2019 (COVID-19).
format Online
Article
Text
id pubmed-8074347
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Singapore
record_format MEDLINE/PubMed
spelling pubmed-80743472021-04-26 Organoid: a powerful tool to study lung regeneration and disease Lu, Tiantian Cao, Yiyuan Zhao, Peng Shen, Shengxi Xi, Ying Cell Regen Review Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, regeneration and disease, and provide an in vitro model for drug screening. This review summarizes the recent advances of organoid cultures derived from adult lung stem cells and human pluripotent stem cells, especially focusing on the organoids of the distal airway stem/progenitor cells. We also discuss the applications of organoids in studying lung regeneration and pulmonary diseases, including pulmonary fibrosis, airway diseases and Coronavirus disease 2019 (COVID-19). Springer Singapore 2021-04-26 /pmc/articles/PMC8074347/ /pubmed/33900491 http://dx.doi.org/10.1186/s13619-021-00082-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lu, Tiantian
Cao, Yiyuan
Zhao, Peng
Shen, Shengxi
Xi, Ying
Organoid: a powerful tool to study lung regeneration and disease
title Organoid: a powerful tool to study lung regeneration and disease
title_full Organoid: a powerful tool to study lung regeneration and disease
title_fullStr Organoid: a powerful tool to study lung regeneration and disease
title_full_unstemmed Organoid: a powerful tool to study lung regeneration and disease
title_short Organoid: a powerful tool to study lung regeneration and disease
title_sort organoid: a powerful tool to study lung regeneration and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074347/
https://www.ncbi.nlm.nih.gov/pubmed/33900491
http://dx.doi.org/10.1186/s13619-021-00082-8
work_keys_str_mv AT lutiantian organoidapowerfultooltostudylungregenerationanddisease
AT caoyiyuan organoidapowerfultooltostudylungregenerationanddisease
AT zhaopeng organoidapowerfultooltostudylungregenerationanddisease
AT shenshengxi organoidapowerfultooltostudylungregenerationanddisease
AT xiying organoidapowerfultooltostudylungregenerationanddisease

Ejemplares similares